a type of protease that liberates kinins from kininogens
kallikrein in American English
(ˌkælɪˈkriɪn)
noun
any of a group of proteolytic enzymes in the blood, urine, etc. that release a kinin from various globulins
Examples of 'kallikrein' in a sentence
kallikrein
The resulting cell fragments trigger the kallikrein—mediated contact phase of coagulation.
Thomas W. Stief M.D. 2007, 'Phospholipase A Activates Hemostasis', Drug Target Insightshttps://doi.org/10.1177/117739280700200019. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The preparation inhibited trypsin and chymotrypsin but was inactive against papain, kallikrein and pepsin.
A. Pawłowski 2015, 'Trypsin inhibitor from starchy endosperm of rye seeds', Acta Societatis Botanicorum Poloniaehttps://pbsociety.org.pl/journals/index.php/asbp/article/view/5062. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Delayed administration of kallikrein after cerebral infarction can improve neurological function.
Yaohui Ni, Kefu Cai, Yujie Hu, Chuan-hui Wang, Yuanyuan Zhang, Hua Huang, Xing Su,Jin-hua Gu 2018, 'The Long-Term Outcome Comparison of Different Time-Delayed Kallikrein Treatments ina Mouse Cerebral Ischemic Model', Stem Cells Internationalhttp://dx.doi.org/10.1155/2018/1706982. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Human plasma kallikrein-kinin system proteins are related to inflammation through bradykinin.
Guacyara Motta, Ivarne L. S. Tersariol 2017, 'Modulation of the Plasma Kallikrein-Kinin System Proteins Performed by Heparan SulfateProteoglycans', Frontiers in Physiologyhttp://journal.frontiersin.org/article/10.3389/fphys.2017.00481/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Excess sodium intake requires the renal kallikrein-kinin system for additional excretion.
Masataka Majima, Makoto Katori 2010, 'A Novel Category of Anti-Hypertensive Drugs for Treating Salt-Sensitive Hypertensionon the Basis of a New Development Concept', Pharmaceuticalshttp://www.mdpi.com/1424-8247/3/1/59/. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Renin-angiotensin and kallikrein-kinin systems are interconnected, regulating blood pressure homeostasis.
Renata R Gatti, Paula S Santos, Angela AS Sena, Karina Marangoni, Messias A Araújo,Luiz R Goulart 2013, 'The interaction of and gene polymorphisms with conventional risk factors increasespredisposition to hypertension', Journal of the Renin-Angiotensin-Aldosterone Systemhttps://doi.org/10.1177/1470320312452027. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Angioedema can be caused by either mast cell degranulation or activation of the kallikrein-kinin cascade.
Allen P. Kaplan 2008, 'Angioedema', World Allergy Organization Journalhttp://www.sciencedirect.com/science/article/pii/S1939455119305848. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In addition, kallikrein inhibition also ameliorated venom-induced blood incoagulability and decreased kidney tissue factor expression.
Markus Berger, João Alfredo de Moraes, Walter Orlando Beys-da-Silva, Lucélia Santi,Paula Barros Terraciano, David Driemeier, Elizabeth Obino Cirne-Lima, Eduardo PandolfiPassos, Maria Aparecida Ribeiro Vieira, Thereza Christina Barja-Fidalgo, Jorge AlmeidaGuimarães 2019, 'Renal and vascular effects of kallikrein inhibition in a model of Lonomia obliquavenom-induced acute kidney injury.', PLoS Neglected Tropical Diseaseshttp://europepmc.org/articles/PMC6392336?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)