No benefit could be attributed to the suramin pre-treatment.
Irene Kuepfer, Caecilia Schmid, Mpairwe Allan, Andrew Edielu, Emma P Haary, AbbasKakembo, Stafford Kibona, Johannes Blum, Christian Burri 2012, 'Safety and efficacy of the 10-day melarsoprol schedule for the treatment of secondstage Rhodesiense sleeping sickness.', PLoS Neglected Tropical Diseaseshttp://europepmc.org/articles/PMC3435133?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Synergism was also observed between paromomycin–suramin and netilmicin–curcumin.
Supriya Khanra, Y. Pavan Kumar, Jyotirmayee Dash, Rahul Banerjee 2018, 'In vitro screening of known drugs identified by scaffold hopping techniques showspromising leishmanicidal activity for suramin and netilmicin', BMC Research Noteshttp://link.springer.com/article/10.1186/s13104-018-3446-y. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Single trials reported improved disease control with estramustine-vinblastine, vinorelbine-hydrocortisone,and suramin-hydrocortisone compared to controls.
Hotte Sébastien, Ernst D Scott, Berry Scott, Waldron Tricia, Winquist Eric, LukkaHimu 2006, 'Non-hormonal systemic therapy in men with hormone-refractory prostate cancer and metastases:a systematic review from the Cancer Care Ontario Program in Evidence-based Care'sGenitourinary Cancer Disease Site Group', BMC Cancerhttp://www.biomedcentral.com/1471-2407/6/112. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Suramin inhibits immune responses and protects cells against inflammatory cell injury.
Honglan Piao, Yuan Chi, Xiling Zhang, Zhen Zhang, Kun Gao, Manabu Niimi, Manabu Kamiyama,Jinming Zhang, Masayuki Takeda, Jian Yao 2016, 'Suramin inhibits antibody binding to cell surface antigens and disrupts complement-mediatedmesangial cell lysis', Journal of Pharmacological Scienceshttp://www.sciencedirect.com/science/article/pii/S1347861316300056. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
She was treated with pentamidine followed by suramin, and recovered 1 month later.
Qin Liu, Xiao-Ling Chen, Mu-Xin Chen, Han-Guo Xie, Qing Liu, Zhu-Yun Chen, Yao-YingLin, Hua Zheng, Jia-Xu Chen, Yi Zhang, Xiao-Nong Zhou 2018, 'Trypanosoma brucei rhodesiense infection in a Chinese traveler returning from theSerengeti National Park in Tanzania', Infectious Diseases of Povertyhttp://link.springer.com/article/10.1186/s40249-018-0432-5. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In suramin-treated embryos, dissociated mesenchyme cells migrated partially by retaining their epithelial morphology.
Norio eWakayama, Tomoko eKatow, Hideki eKatow 2013, 'Characterization and endocytic internalization of Epith-2 cell surface glycoproteinduring the epithelial-to-mesenchymal transition in sea urchin embryos', Frontiers in Endocrinologyhttp://journal.frontiersin.org/Journal/10.3389/fendo.2013.00112/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Suramin had no effect on enzyme activity.
Luciane Almeri Tabaldi, Raquel Ruppenthal, Luciane Belmonte Pereira, Denise Cargnelutti,Jamile Fabbrin Gonçalves, Vera Maria Morsch, Maria Rosa Chitolina Schetinger 2008, 'Presence of multiple acid phosphatases activity in seedlings of cucumber, radish androcket salad Presença de atividade de múltiplas fosfatases ácidas em plântulas depepino, rabanete e rúcula', Ciência Ruralhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782008000300009. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Suramin was given at 10 mg/kg once per week for two weeks.
Na Liu, Song He, Evelyn Tolbert, Rujun Gong, George Bayliss, Shougang Zhuang 2012, 'Suramin alleviates glomerular injury and inflammation in the remnant kidney.', PLoS ONEhttp://europepmc.org/articles/PMC3338607?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These effects were blocked by suramin.
Stefan G Mattyasovszky, Jochen Wollstädter, Anne Martin, Ulrike Ritz, Andreas Baranowski,Christian Ossendorf, Pol M Rommens, Alexander Hofmann 2016, 'Inhibition of Contractile Function in Human Joint Capsule Myofibroblasts by Targetingthe TGF-β1 and PDGF Pathways.', PLoS ONEhttp://europepmc.org/articles/PMC4712129?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)