This local enhancement of the propensity to separate to single strands under superhelical stress has obvious implications for origin function.
Prashanth Ak, Craig J Benham 2005, 'Susceptibility to superhelically driven DNA duplex destabilization: a highly conservedproperty of yeast replication origins.', PLoS Computational Biologyhttp://europepmc.org/articles/PMC1183513?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Our numerical approach generalizes the strategy of previously developed algorithms, which studied superhelical transitions to a single alternate conformation.
Dina Zhabinskaya, Craig J Benham 2012, 'Theoretical analysis of competing conformational transitions in superhelical DNA.',PLoS Computational Biologyhttp://europepmc.org/articles/PMC3343103?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Recently determined crystal structures show that their common architecture reveals a superhelical overall structure that may undergo drastic conformational changes.
Holger Flechsig 2014, 'TALEs from a spring--superelasticity of Tal effector protein structures.', PLoS ONEhttp://europepmc.org/articles/PMC4196931?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This 10 bp periodicity implies an ordered superhelical intrinsic structure for the average chromatin fiber in yeast.
Ji-Ping Wang, Yvonne Fondufe-Mittendorf, Liqun Xi, Guei-Feng Tsai, Eran Segal, JonathanWidom 2008, 'Preferentially quantized linker DNA lengths in Saccharomyces cerevisiae.', PLoS Computational Biologyhttp://europepmc.org/articles/PMC2522279?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Rather, superhelical stresses provide long-range coupling among the transition behaviors of all base pairs within a topologically constrained domain.
Prashanth Ak, Craig J Benham 2005, 'Susceptibility to superhelically driven DNA duplex destabilization: a highly conservedproperty of yeast replication origins.', PLoS Computational Biologyhttp://europepmc.org/articles/PMC1183513?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)