Helenalin acetate could hence be a useful anti-leishmanial scaffold for further optimization studies.
Imke F. Wulsten, Thais A. Costa-Silva, Juliana T. Mesquita, Marta L. Lima, MarianaK. Galuppo, Noemi N. Taniwaki, Samanta E. T. Borborema, Fernando B. Da Costa, ThomasJ. Schmidt, Andre G. Tempone 2017, 'Investigation of the Anti-Leishmania (Leishmania) infantum Activity of Some NaturalSesquiterpene Lactones', Moleculeshttp://www.mdpi.com/1420-3049/22/5/685. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Mammalian protection against leishmanial infection depends on the development of an effective immune response.
Neci M. Soares, Joelma N. de Souza, Tatiana F. Leal, Eliana A. G. Reis, Maria S. Miranda,Washington L. C. dos Santos, Márcia C. A. Teixeira 2017, 'Sera from Visceral Leishmaniasis Patients Display Oxidative Activity and Affect theTNF-α Production by Macrophages In Vitro', BioMed Research Internationalhttp://dx.doi.org/10.1155/2017/5861453. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Thus, this molecule has demonstrated potential as an anti-leishmanial agent.
Carlos Eduardo Sampaio Guedes, Beatriz Rocha Simões Dias, Antonio Luis de OliveiraAlmeida Petersen, Kercia Pinheiro Cruz, Niara de Jesus Almeida, Daniela RodriguesAndrade, Juliana Perrone Bezerra de Menezes, Valéria de Matos Borges, Patricia SampaioTavares Veras 2018, 'In vitro evaluation of the anti-leishmanial activity and toxicity of PK11195', Memórias do Instituto Oswaldo Cruz.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018000400300&lng=en&tlng=en. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
All prepared extracts were tested for their anti-leishmanial activity.
Salwa Bouabdallah, Dhafer Laouini, Nabiha Bouzouita, Safia El-Bok, Rabiaa M. Sghaier,Sawssen Selmi, Mossadok Ben Attia 2018, 'Separation and evaluation of natural antileishmanial potential against Leishmaniamajor and infuntum isolated from the Tunisia strains', Bangladesh Journal of Pharmacologyhttps://www.banglajol.info/index.php/BJP/article/view/33908. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The aim of this study was analysis of antimicrobial, cytotoxic, phytotoxic, insecticidal, and anti-leishmanial activity.
Fiaz Alam, Qazi Najam us Saqib 2017, 'Evaluation of Zanthoxylum armatum Roxb for in vitro biological activities', Journal of Traditional and Complementary Medicinehttp://www.sciencedirect.com/science/article/pii/S2225411017300111. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Primary isolation of eight stocks of leishmanial parasites was achieved from patients with active lesions.
C.A. Cuba Cuba, C.O. Torno, O. Ledesma, E. Visciarelli, S. Garcia, M.I. Prat, R. Costamagna,L. Barbieri, D.A. Evans 1996, 'Human cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis in Santiagodel Estero, Argentina: identification of parasites by monoclonal antibodies and isoenzymesLeishmaniose cutânea humana causada por Leishmania (Viannia) braziliensis na Provínciade Santiago del Estero, Argentina: identificação dos parasitas por anticorpos monoclonaise isoenzimas', Revista do Instituto de Medicina Tropical de São Paulohttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651996000600005. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The results show measurable in vitro anti-leishmanial activity for three compounds.
Strahinja Stevanovic, Milan Sencanski, Mathieu Danel, Christophe Menendez, RoumaissaBelguedj, Abdelmalek Bouraiou, Katarina Nikolic, Sandrine Cojean, Philippe M. Loiseau,Sanja Glisic, Michel Baltas, Alfonso T. García-Sosa 2019, 'Synthesis, In Silico, and In Vitro Evaluation of Anti-Leishmanial Activity of Oxadiazolesand Indolizine Containing Compounds Flagged against Anti-Targets', Moleculeshttps://www.mdpi.com/1420-3049/24/7/1282. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)