a crystalline soluble basic heterocyclic compound; 1,2-diazole. Formula: C3H4N2
Word origin
C19: from German, from pyrrole + inserted -az- (see azo-)
pyrazole in American English
(ˈpɪrəˌzoul, -ˌzɔl)
noun Chemistry
1.
any of the group of heterocyclic compounds containing three carbon atoms, two adjacent nitrogen atoms, and two double bonds in the ring
2.
the parent compound, C3H4N2
Word origin
[1885–90; pyr- + azole]This word is first recorded in the period 1885–90. Other words that entered Englishat around the same time include: booster, roller coaster, seminar, upsweep, zoom
Examples of 'pyrazole' in a sentence
pyrazole
The pyrazole ring adopts a twisted comformation.
Hoong-Kun Fun, Ching Kheng Quah, Hasnah Osman, Chuan-Wei Oo, Mohammad Asad 2010, '4-[(E)-(4-Hydroxy-2-oxo-2H-chromen-3-yl)methylideneamino]-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-onemonohydrate', Acta Crystallographica Section Ehttp://scripts.iucr.org/cgi-bin/paper?S160053681003480X. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Fused pyrazole ring systems are common structural motifs of numerous pharmaceutically important compounds.
Vaida Milišiūnaitė, Rūta Paulavičiūtė, Eglė Arbačiauskienė, Vytas Martynaitis, WolfgangHolzer, Algirdas Šačkus 2019, 'Synthesis of 2H-furo[2,3-c]pyrazole ring systems through silver(I) ion-mediated ring-closurereaction', Beilstein Journal of Organic Chemistryhttps://doi.org/10.3762/bjoc.15.62. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Examples of a linked benzotriazole and pyrazole motif were also prepared.
Paul E. Floreancig, Lei Liu, Peter Wipf, Matthew G. LaPorte, Ramy Farid, Nilesh Zaware 2011, 'Diversity-Oriented Synthesis of a Library of Substituted Tetrahydropyrones Using OxidativeCarbon-Hydrogen Bond Activation and Click Chemistry', Moleculeshttp://www.mdpi.com/1420-3049/16/5/3648/. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Pyrazole chalcones were synthesized by the reaction of pyrazole aldehydes and suitable aromatic ketones.
Sankappa Rai U., A.M. Isloor, P. Shetty, K.S.R. Pai, H.K. Fun 2015, 'Synthesis and in vitro biological evaluation of new pyrazole chalcones and heterocyclicdiamides as potential anticancer agents', Arabian Journal of Chemistryhttp://www.sciencedirect.com/science/article/pii/S1878535214000215. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The results showed that some of the synthesized pyrazole carboxamides displayed notable antifungal activity.
Jialong Sun, Yuanming Zhou 2015, 'Synthesis and Antifungal Activity of the Derivatives of Novel Pyrazole Carboxamideand Isoxazolol Pyrazole Carboxylate', Moleculeshttp://www.mdpi.com/1420-3049/20/3/4383. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Pyrrole, pyrazole, indoles, carbazoles, and diarylamines were successfully vinylated in goodyields.
Konstantin S. Rodygin, Alexander S. Bogachenkov, Valentine P. Ananikov 2018, 'Vinylation of a Secondary Amine Core with Calcium Carbide for Efficient Post-Modificationand Access to Polymeric Materials', Moleculeshttp://www.mdpi.com/1420-3049/23/3/648. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Coumarins appended to benzimidazole through pyrazole are designed and synthesized using microwave irradiation.
Mahadev N. Kumbar, Ravindra R. Kamble, Atulkumar A. Kamble, Sujith Raj Salian, SandhyaKumari, Ramya Nair, Guruprasad Kalthur, Satish Kumar Adiga, D. Jagadeesh Prasad 2016, 'Design and Microwave Assisted Synthesis of Coumarin Derivatives as PDE Inhibitors',International Journal of Medicinal Chemistryhttp://dx.doi.org/10.1155/2016/9890630. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
A series of pyrazole derivatives 9-22 were designed and synthesized.
Radwan Awwad A., Ghorab Mostafa M., Alsaid Mansour S., Alanazi Fares K. 2014, 'Novel Ethyl 1,5-Disubstituted-1H-Pyrazole-3-Carboxylates as a New Class of AntimicrobialAgents', Acta Pharmaceuticahttp://www.degruyter.com/view/j/acph.2014.64.issue-3/acph-2014-0028/acph-2014-0028.xml?format=INT. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The pyrazole ring in each molecule has an envelope conformation.
Dong-Qiang Guo, Ji-Liang Wang, Sheng-Hai Guo, Xin-Ying Zhang 2012, '1-[5-(2-Chlorophenyl)-5-hydroxy-3-methyl-4,5-dihydro-1H-pyrazol-1-yl]ethanone', Acta Crystallographica Section Ehttp://scripts.iucr.org/cgi-bin/paper?S1600536812007283. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)