a process whereby the genome of a virus is exposed in order for the virus to replicate
Examples of 'uncoating' in a sentence
uncoating
Upon uncoating and fusion, the virus should exit to the cytosol to start replication.
Miguel Ángel Cuesta-Geijo, Lucía Barrado-Gil, Inmaculada Galindo, Raquel Muñoz-Moreno,Covadonga Alonso 2017, 'Redistribution of Endosomal Membranes to the African Swine Fever Virus ReplicationSite', Viruseshttp://www.mdpi.com/1999-4915/9/6/133. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Uncoating occurs both in the cytoplasm and at the nuclear membrane.
Ashwanth C Francis, Mariana Marin, Jiong Shi, Christopher Aiken, Gregory B Melikyan 2016, 'Time-Resolved Imaging of Single HIV-1 Uncoating In Vitro and in Living Cells.', PLoS Pathogenshttp://europepmc.org/articles/PMC4913920?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Unexpectedly, genome uncoating was blocked by inhibiting ubiquitination.
Laura A. Byk, Néstor G. Iglesias, Federico A. De Maio, Leopoldo G. Gebhard, MarioRossi, Andrea V. Gamarnik 2016, 'Dengue Virus Genome Uncoating Requires Ubiquitination', mBiohttp://mbio.asm.org/cgi/content/full/7/3/e00804-16. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Here, we examined for the first time molecular aspects of dengue virus genome uncoating.
Laura A. Byk, Néstor G. Iglesias, Federico A. De Maio, Leopoldo G. Gebhard, MarioRossi, Andrea V. Gamarnik 2016, 'Dengue Virus Genome Uncoating Requires Ubiquitination', mBiohttp://mbio.asm.org/cgi/content/full/7/3/e00804-16. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This property correlated with an improved vector uncoating.
Axel Rossi, Léa Dupaty, Ludovic Aillot, Liang Zhang, Célia Gallien, Michael Hallek,Margarete Odenthal, Sahil Adriouch, Anna Salvetti, Hildegard Büning 2019, 'Vector uncoating limits adeno-associated viral vector-mediated transduction of humandendritic cells and vector immunogenicity', Scientific Reportshttp://link.springer.com/article/10.1038/s41598-019-40071-1. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In addition, we were able to recapitulate viral uncoating and transcription mechanisms directed onto the microchip surfaces.
Deborah F. Kelly, Sarah M. McDonald, Madeline J. Dukes, Allison O. McKell, CrystalE. Boudreaux, Justin R. Tanner, Brian L. Gilmore 2013, 'Molecular Surveillance of Viral Processes Using Silicon Nitride Membranes', Micromachineshttp://www.mdpi.com/2072-666X/4/1/90. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The intracellular compartment where uncoating takes place, the required capsid structural rearrangements and the cellular factors involved remain unknown.
Oliver Caliaro, Andrea Marti, Nico Ruprecht, Remo Leisi, Suriyasri Subramanian, SusanHafenstein, Carlos Ros 2019, 'Parvovirus B19 Uncoating Occurs in the Cytoplasm without Capsid Disassembly and ItIs Facilitated by Depletion of Capsid-Associated Divalent Cations', Viruseshttps://www.mdpi.com/1999-4915/11/5/430. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Uncoating and nuclear entry was independent of proteasome function and resistant to inhibitors of nuclear export.
Eiki Sekine, Nora Schmidt, David Gaboriau, Peter O'Hare 2017, 'Spatiotemporal dynamics of HSV genome nuclear entry and compaction state transitionsusing bioorthogonal chemistry and super-resolution microscopy.', PLoS Pathogenshttp://europepmc.org/articles/PMC5697887?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Key stages of the viral cycle such as virus uncoating, transport and maturation are ion-influenced processes in many viral species.
Jose L. Nieto-Torres, Carmina Verdiá-Báguena, Carlos Castaño-Rodriguez, Vicente M.Aguilella, Luis Enjuanes 2015, 'Relevance of Viroporin Ion Channel Activity on Viral Replication and Pathogenesis',Viruseshttp://www.mdpi.com/1999-4915/7/7/2786. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Validation and analysis of clustered hits revealed previously unknown processes during virus entry, including a mechanism for genomeuncoating.
Jason Mercer, Berend Snijder, Raphael Sacher, Christine Burkard, Christopher Karl ErnstBleck, Henning Stahlberg, Lucas Pelkmans, Ari Helenius 2012, 'RNAi Screening Reveals Proteasome- and Cullin3-Dependent Stages in Vaccinia VirusInfection', Cell Reportshttp://www.sciencedirect.com/science/article/pii/S2211124712002847. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)