a type of porphyrin that, when combined with an iron atom, forms haem, the oxygen-bearing prosthetic group of the red blood pigment haemoglobin
Examples of 'protoporphyrin' in a sentence
protoporphyrin
Protoporphyrin accumulation causes bile injury and ductular reaction.
Sathidpak Nantasanti, Mathilda J. M. Toussaint, Sameh A. Youssef, Peter C. J. Tooten,Alain de Bruin 2016, 'Rb and p53 Liver Functions Are Essential for Xenobiotic Metabolism and Tumor Suppression',PLOS ONE10.1371/journal.pone.0150064. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Cobalt protoporphyrin may be a more promising therapeutic agent to upregulate some antioxidantive genes.
Xiaojun Liu, Ying Cui, Meixia Li, Haifeng Xu, Jin Zuo, Fude Fang, Yongsheng Chang 2013, 'Cobalt protoporphyrin induces HO-1 expression mediated partially by FOXO1 and reducesmitochondria-derived reactive oxygen species production.', PLoS ONEhttp://europepmc.org/articles/PMC3821864?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
On laboratory investigation, both total and free protoporphyrin were elevated.
James Kiberd, Laura Finlayson 2018, 'Delayed photosensitivity in a child with erythropoietic protoporphyria : a case report',SAGE Open Medical Case Reportshttps://doi.org/10.1177/2050313X18772125. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Halophilic euryarchaea lack many of the genes necessary for the protoporphyrin-dependent heme biosynthesis pathway previously identified in animals and plants.
Naoki Kosugi, Takuma Araki, Junpei Fujita, Satoru Tanaka, Taketomo Fujiwara 2017, 'Growth phenotype analysis of heme synthetic enzymes in a halophilic archaeon, Haloferaxvolcanii', PLOS ONE10.1371/journal.pone.0189913. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In contrast, protoporphyrin was detected in both the eggshells of several avian species and in the shells of all mollusks.
Aida Verdes, Wooyoung Cho, Marouf Hossain, Patricia L. R. Brennan, Daniel Hanley,Tomáš Grim, Mark E. Hauber, Mandë Holford 2015, 'Nature's Palette: Characterization of Shared Pigments in Colorful Avian and MolluskShells', PLOS ONE10.1371/journal.pone.0143545. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, the naringin's protective effects on sepsis-induced lung injury were eliminated by zinc protoporphyrin, a heme oxygenase 1 competitive inhibitor.
Minchan Gil, Yun Kyu Kim, Sang Bum Hong, Kyung Jin Lee 2016, 'Naringin Decreases TNF-α and HMGB1 Release from LPS-Stimulated Macrophages and ImprovesSurvival in a CLP-Induced Sepsis Mice.', PLoS ONEhttp://europepmc.org/articles/PMC5055320?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Lead was determined by atomic absorption spectrophotometry; hemoglobin by automated cell counting; zinc protoporphyrin by hematofluorometry; ferritin by chemiluminescence.
Rondó Patrícia H C, Carvalho Maria de Fátima H, Souza Miriam C, Moraes Flávio 2006, 'Lead, hemoglobin, zinc protoporphyrin and ferritin concentrations in children', Revista de Saúde Públicahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89102006000100012. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Some bacteria produce hemophores (similar to siderophores) intended for obtainingiron from exogenous heme (iron protoporphyrin).
А.Е. Abaturov, Т.А. Kryuchko 2018, 'Drug limitation of the availability of iron ions for pathogenic bacteria (part 1)',Zdorovʹe Rebenkahttp://childshealth.zaslavsky.com.ua/article/view/137030. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
On the contrary, protoporphyrin accumulation – but not anemia – was present following initiation of exposure at 24 hpf.
Jessica K. Leet, Rachel A. Hipszer, David C. Volz 2015, 'Butafenacil: A positive control for identifying anemia- and variegate porphyria-inducingchemicals', Toxicology Reportshttp://www.sciencedirect.com/science/article/pii/S2214750015300263. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)