any of various compounds consisting of a protein bonded to a mucopolysaccharide chain
proteoglycan in American English
(ˌproutiouˈɡlaikæn)
noun
Biochemistry
a macromolecule composed of a polysaccharide joined to a polypeptide and forming the ground substance of connective tissue
Word origin
[1969; prote(in) + -o- + glyc- + -an, var. of -ane]-o- is the typical ending of the first element of compounds of Greek origin (as -i- is, in compounds of Latin origin), used regularly in forming new compounds with elementsof Greek origin and often used in English as a connective irrespective of etymology(Franco-Italian; geography; seriocomic; speedometer)
Examples of 'proteoglycan' in a sentence
proteoglycan
The proteoglycan can be structurally modified by the enzyme heparanase.
Linda Karlsson-Lindahl, Linnéa Schmidt, David Haage, Caroline Hansson, Magdalena Taube,Emil Egeciouglu, Ying-xia Tan, Therese Admyre, John-Olov Jansson, Israel Vlodavsky,Jin-Ping Li, Ulf Lindahl, Suzanne L. Dickson 2012, 'Heparanase Affects Food Intake and Regulates Energy Balance in Mice', PLoS ONE10.1371/journal.pone.0034313. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This enzyme post-translationally modifies proteoglycan prior to its deposition in the cartilage extracellular matrix.
Louise N. Reynard, Madhushika Ratnayake, Mauro Santibanez-Koref, John Loughlin 2016, 'Functional Characterization of the Osteoarthritis Susceptibility Mapping to CHST11—ABioinformatics and Molecular Study', PLOS ONE10.1371/journal.pone.0159024. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The purified bioflocculant was a proteoglycan consisting of 69.61% carbohydrate and 21.56% protein (wt/wt).
Zhen Chen, Zhipeng Li, Peize Liu, Yu Liu, Yuanpeng Wang, Qingbiao Li, Ning He 2017, 'Characterization of a novel bioflocculant from a marine bacterium and its applicationin dye wastewater treatment', BMC Biotechnologyhttp://link.springer.com/article/10.1186/s12896-017-0404-z. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Three days post-loading, conditioned media were assessed for proteoglycan content and released cytokines.
B Alkhatib, DH Rosenzweig, E Krock, PJ Roughley, L Beckman, T Steffen, MH Weber, JAOuellet, L Haglund 2014, 'Acute mechanical injury of the human intervertebral disc: link to degeneration andpain', European Cells & Materialshttp://www.ecmjournal.org/journal/papers/vol028/pdf/v028a08.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Additionally, the collagen and proteoglycan content in the pellet was quantified.
Akira Ito, Tomoki Aoyama, Hirotaka Iijima, Kohei Nishitani, Junichi Tajino, HiroshiKuroki 2019, 'Periodic mild heat stimuli diminish extracellular matrix synthesis in pellet culturedhuman chondrocytes', BMC Research Noteshttp://link.springer.com/article/10.1186/s13104-019-4058-x. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Mechanisms of action may involve alteration of heparan sulfate proteoglycan-dependent functions in inflammatory cells.
Patsch Josef R, Ricevuti Giovanni, Ross Christopher R, Kaneider Nicole C, MosheimerBirgit, Djanani Angela, Wiedermann Christian J 2006, 'Heparan sulfate proteoglycan-dependent neutrophil chemotaxis toward PR-39 cathelicidin',Journal of Inflammationhttp://www.journal-inflammation.com/content/3/1/14. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Femorotibial joint cartilage integrity was determined by chondropathy scoring and histological staining of proteoglycan.
Mhairi A. Macfadyen, Zoe Daniel, Sara Kelly, Tim Parr, John M. Brameld, Andrew J.Murton, Simon W. Jones 2019, 'The commercial pig as a model of spontaneously-occurring osteoarthritis', BMC Musculoskeletal Disordershttp://link.springer.com/article/10.1186/s12891-019-2452-0. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Lumican, a small leucine-rich proteoglycan of the extracellular matrix, presents potent anti-tumor properties.
Katarzyna Pietraszek, Stéphane Brézillon, Corinne Perreau, Maria Malicka-Błaszkiewicz,François-Xavier Maquart, Yanusz Wegrowski 2013, 'Lumican - derived peptides inhibit melanoma cell growth and migration.', PLoS ONEhttp://europepmc.org/articles/PMC3788744?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Proteoglycan contents and gene expression were decreased and downregulated obviously.
Jia-Wen Zhan, Min-Shan Feng, Li-Guo Zhu, Ping Zhang, Jie Yu 2016, 'Effect of Static Load on the Nucleus Pulposus of Rabbit Intervertebral Disc MotionSegment in an Organ Culture', BioMed Research Internationalhttp://dx.doi.org/10.1155/2016/2481712. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Pellets were stained with toluidine blue to assess proteoglycan deposition.
Alexis L. Gale, Renata L. Linardi, George McClung, Renata M. Mammone, Kyla F. Ortved 2019, 'Comparison of the Chondrogenic Differentiation Potential of Equine Synovial Membrane-Derivedand Bone Marrow-Derived Mesenchymal Stem Cells', Frontiers in Veterinary Sciencehttps://www.frontiersin.org/article/10.3389/fvets.2019.00178/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)