the absence of antibody production in response to the presence of antigens, usually as a result of previous exposure to the antigens
Examples of 'immunological tolerance' in a sentence
immunological tolerance
This profile suggests immunological tolerance.
Roselayne Ferro Furtado, Maria Izabel Florindo Guedes, Carlucio Roberto Alves, AnaCristina de Oliveira Monteiro Moreira, Wagner Pereira Felix, Rosa Amália Fireman Dutra 2011, 'Produção de anticorpos policlonais anti-ricina Production of polyclonal anti-ricinantibodies', Ciência e Agrotecnologiahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-70542011000100015. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, this immunological tolerance can be influenced by intrauterine infections.
Hossein Motedayyen, Farshid Fathi, Mahdi Fasihi-Ramandi, Ali Mohammad Sabzghabaee,Ramezan Ali Taheri 2019, 'Toll-like receptor 4 activation on human amniotic epithelial cells is a risk factorfor pregnancy loss', Journal of Research in Medical Scienceshttp://www.jmsjournal.net/article.asp?issn=1735-1995;year=2019;volume=24;issue=1;spage=1;epage=1;aulast=Motedayyen. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Failure or breakdown of immunological tolerance results in autoimmunity.
Nicla Porciello, Martina Kunkl, Loretta Tuosto 2018, 'CD28 between tolerance and autoimmunity: the side effects of animal models [version1; referees: 2 approved]', F1000Researchhttps://f1000research.com/articles/7-682/v1. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This could be the result of immunological tolerance and possibly increases vulnerabilitytowards secondary infections.
Rebecca M Koch, Matthijs Kox, Corné van den Kieboom, Gerben Ferwerda, Jelle Gerretsen,Sandra Ten Bruggencate, Johannes G van der Hoeven, Marien I de Jonge, Peter Pickkers 2018, 'Short-term repeated HRV-16 exposure results in an attenuated immune response in vivoin humans.', PLoS ONEhttp://europepmc.org/articles/PMC5813921?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Rather, we suggest the possibility of a transitory dysfunction in immunological tolerance mechanisms.
Marcelo Cruz Rezende, Arlete Delfina Marques Maia, Alex Magno Coelho Horimoto 2005, 'Reumatismo pós-quimioterapia: uma disfunção da tolerância imunológica? Post-chemotherapyrheumatism: an immunological tolerance dysfunction?', Revista Brasileira de Reumatologiahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042005000100009. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
They are responsible for deactivating the immune system and enhancing immunological tolerance.
Farouk Tijjani Saad, Evren Hincal, Bilgen Kaymakamzade 2017, 'Dynamics of Immune Checkpoints, Immune System, and BCG in the Treatment of SuperficialBladder Cancer', Computational and Mathematical Methods in Medicinehttp://dx.doi.org/10.1155/2017/3573082. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Yet, the mechanisms of immunological tolerance toward muscle autoantigens remain mostly unknown.
Emilie Franck, Carole Bonneau, Laetitia Jean, Jean-Paul Henry, Yann Lacoume, AnnaSalvetti, Olivier Boyer, Sahil Adriouch 2012, 'Immunological tolerance to muscle autoantigens involves peripheral deletion of autoreactiveCD8+ T cells.', PLoS ONEhttp://europepmc.org/articles/PMC3343038?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
They play an important role in the induction and maintenance of immunological tolerance.
Bogusław Nedoszytko, Magdalena Lange, Małgorzata Sokołowska-Wojdyło, Joanna Renke,Piotr Trzonkowski, Michał Sobjanek, Aneta Szczerkowska-Dobosz, Marek Niedoszytko,Aleksandra Górska, Jan Romantowski, Justyna Czarny, Jarosław Skokowski, Leszek Kalinowski,Roman Nowicki 2017, 'The role of regulatory T cells and genes involved in their differentiation in pathogenesisof selected inflammatory and neoplastic skin diseases. Part II: The Treg role in skindiseases pathogenesis', Advances in Dermatology and Allergologyhttps://www.termedia.pl/The-role-of-regulatory-T-cells-and-genes-involved-in-their-differentiation-in-pathogenesis-of-selected-inflammatory-and-neoplastic-skin-diseases-Part-II-The-Treg-role-in-skin-diseases-pathogenesis,7,30898,1,1.html. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Previous work has established that both subsets are required for immunological tolerance.
Erica G Schmitt, Calvin B Williams 2013, 'Generation and function of induced regulatory T cells', Frontiers in Immunologyhttp://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00152/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)