a quinone derivative, present in biological cells, that functions as an electron carrier in the electron transport chain
Also called: ubiquinone
Examples of 'ubiquinone' in a sentence
ubiquinone
Eukaryotic cells can synthesize ubiquinone but not menaquinone, whereas prokaryotes can synthesize both quinones.
Dmitry A Ravcheev, Ines eThiele 2016, 'Genomic analysis of the human gut microbiome suggests novel enzymes involved in quinonebiosynthesis', Frontiers in Microbiologyhttp://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00128/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Its crystal structure in complex with the electron acceptor, ubiquinone, has been determined.
Tetsuo Yamashita, Daniel Ken Inaoka, Tomoo Shiba, Takumi Oohashi, So Iwata, TakaoYagi, Hiroaki Kosaka, Hideto Miyoshi, Shigeharu Harada, Kiyoshi Kita, Katsuya Hirano 2018, 'Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures bindingnovel competitive- and mixed-type inhibitors', Scientific Reportshttp://link.springer.com/article/10.1038/s41598-018-20775-6. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
On the other hand, there was decrease in the concentration of plasma ubiquinone.
Ravikumar A, Jyothi J k, Leelamma S, Kurup P A 1999, 'Isoprenoid Pathway And Neurological And Psychiatric Disorders', Annals of Indian Academy of Neurologyhttp://www.annalsofian.org/article.asp?issn=0972-2327;year=1999;volume=2;issue=3;spage=129;epage=135;aulast=Ravikumar;type=0. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, there has been controversy regarding the ubiquinone binding site.
Tetsuo Yamashita, Daniel Ken Inaoka, Tomoo Shiba, Takumi Oohashi, So Iwata, TakaoYagi, Hiroaki Kosaka, Hideto Miyoshi, Shigeharu Harada, Kiyoshi Kita, Katsuya Hirano 2018, 'Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures bindingnovel competitive- and mixed-type inhibitors', Scientific Reportshttp://link.springer.com/article/10.1038/s41598-018-20775-6. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Most of the enzymes use ubiquinone as one of their substrates.
Čermáková Petra, Kovalinka Tomáš, Ferenczyová Kristína, Horváth Anton 2019, 'Coenzyme Q2 is a universal substrate for the measurement of respiratory chain enzymeactivities in trypanosomatids', Parasitehttps://www.parasite-journal.org/articles/parasite/full_html/2019/01/parasite180165/parasite180165.html. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Unexpectedly, rad-8 regrowth defects were suppressed by altered function in the ubiquinone biosynthesis gene clk-1.
Wendy M. Knowlton, Thomas Hubert, Zilu Wu, Andrew D. Chisholm, Yishi Jin, Yishi Jin,Yishi Jin 2017, 'A Select Subset of Electron Transport Chain Genes Associated with Optic Atrophy LinkMitochondria to Axon Regeneration in Caenorhabditis elegans', Frontiers in Neurosciencehttp://journal.frontiersin.org/article/10.3389/fnins.2017.00263/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
High levels of plasma ubiquinol-10/ubiquinone-10 ratio indicate the protective effect on diabetic retinopathy.
Orhan Ates, Habip Bilen, Sadullah Keles, H. Hakan Alp, Mevlüt Sait Keleş, Kenan Yıldırım,Osman Öndaş, L. Can Pınar, Mustafa Civelekler, Orhan Baykal 2013, 'Plasma coenzyme Q10 levels in type 2 diabetic patients with retinopathy', International Journal of Ophthalmologyhttp://www.ijo.cn/en_publish/2013/5/20130525.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Acylcarnitines are mainly in the skeletal muscle, gluteus and soleus, while heart presents higher levels of ubiquinone than other tissues.
Irene Pradas, Kevin Huynh, Rosanna Cabré, Victòria Ayala, Peter J. Meikle, MarionaJové, Reinald Pamplona 2018, 'Lipidomics Reveals a Tissue-Specific Fingerprint', Frontiers in Physiologyhttps://www.frontiersin.org/article/10.3389/fphys.2018.01165/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Correlation analysis revealed a significant positive correlation between ubiquinone and the scores of backward digit span abilities.
Ehab Ragaa Abdelraouf, Ayman Kilany, Adel F. Hashish, Ola Hosny Gebril, Suzette IbrahimHelal, Haytham Mohamad Hasan, Neveen Hassan Nashaat 2018, 'Investigating the influence of ubiquinone blood level on the abilities of childrenwith specific learning disorder', The Egyptian Journal of Neurology, Psychiatry and Neurosurgeryhttp://link.springer.com/article/10.1186/s41983-018-0029-8. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This work provides the first detailed structural information of an important and highly conserved enzyme of ubiquinone biosynthesis.
Alexandre Ismail, Vincent Leroux, Myriam Smadja, Lucie Gonzalez, Murielle Lombard,Fabien Pierrel, Caroline Mellot-Draznieks, Marc Fontecave 2016, 'Coenzyme Q Biosynthesis: Evidence for a Substrate Access Channel in the FAD-DependentMonooxygenase Coq6.', PLoS Computational Biologyhttp://europepmc.org/articles/PMC4726752?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)