Clinical features of hyperphagic reactions were found.
O. A. Gladyshev 2014, 'HYPERPHAGIA REACTIONS WITHIN EATING DISORDERS. CLINICAL FEATURES AND THERAPY', Racionalʹnaâ Farmakoterapiâ v Kardiologiihttps://www.rpcardio.com/jour/article/view/23. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
They are grossly overweight and hyperphagic, particularly at young ages, and develop severe insulin resistance.
Per Lindström 2007, 'The Physiology of Obese-Hyperglycemic Mice [ob/ob Mice]', The Scientific World Journalhttp://dx.doi.org/10.1100/tsw.2007.117. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
After restriction, both gorgers and non-gorgers were hyperphagic until their lost weight was regained.
Catherine Hambly, John R. Speakman 2015, 'Mice that gorged during dietary restriction increased foraging related behaviors anddiffered in their macronutrient preference when released from restriction', PeerJhttps://peerj.com/articles/1091.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The fat-induced decrease may explain part of the hyperphagic effect of high-fat diets.
Thi Ai Diep, Andreas N Madsen, Sandra Krogh-Hansen, Marwa Al-Shahwani, Laila Al-Sabagh,Birgitte Holst, Harald S Hansen 2014, 'Dietary non-esterified oleic Acid decreases the jejunal levels of anorectic N-acylethanolamines.',PLoS ONEhttp://europepmc.org/articles/PMC4068999?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Intriguingly, mutant males exhibited a hyperphagic behavior only during the resting (diurnal) phase of the light cycle.
Clara Rossetti, Daniel Sciarra, Jean-Marie Petit, Chin B. Eap, Olivier Halfon, PierreJ. Magistretti, Benjamin Boutrel, Jean-René Cardinaux 2017, 'Gender-specific alteration of energy balance and circadian locomotor activity in theCrtc1 knockout mouse model of depression', Translational Psychiatryhttp://link.springer.com/article/10.1038/s41398-017-0023-4. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
A strong correlation also existed between the takeout gene and hyperphagic behavior in both males and females.
Tsering Stobdan, Debashis Sahoo, Priti Azad, Iain Hartley, Erilynn Heinrichsen, DanZhou, Gabriel G Haddad 2019, 'High fat diet induces sex-specific differential gene expression in Drosophila melanogaster.',PLoS ONEhttp://europepmc.org/articles/PMC6413938?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)