a drug which prevents the development of tumours and is used in the treatment of certain types of cancer as well as in the treatment of sickle-cell disease and AIDS
hydroxyurea in American English
(haiˌdrɑksijuˈriə, -ˈjuriə)
noun
Pharmacology
a synthetic compound, CH4N2O2, used in cancer therapy
Word origin
[1945–50; hydroxy- + urea]This word is first recorded in the period 1945–50. Other words that entered Englishat around the same time include: ergative, on-line, poison pill, shootout, synchronized swimminghydroxy- is a combining form used in the names of chemical compounds in which the hydroxylgroup is present. Other words that use the affix hydroxy- include: hydroxyapatite, hydroxychloroquine, hydroxyketone, hydroxyzine, trihydroxy
Examples of 'hydroxyurea' in a sentence
hydroxyurea
Our previous study showed a reduction in serum ferritin of β-thalassemia patients on hydroxyurea therapy.
Khushnooma Italia, Roshan Colah, Kanjaksha Ghosh 2013, 'Hydroxyurea Could Be a Good Clinically Relevant Iron Chelator', PLoS ONE10.1371/journal.pone.0082928. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Most participants (74%) reported low hydroxyurea adherence.
Sherif M. Badawy, Alexis A. Thompson, Jin-Shei Lai, Frank J. Penedo, Karen Rychlik,Robert I. Liem 2017, 'Adherence to hydroxyurea, health-related quality of life domains, and patients' perceptionsof sickle cell disease and hydroxyurea: a cross-sectional study in adolescents andyoung adults', Health and Quality of Life Outcomeshttp://link.springer.com/article/10.1186/s12955-017-0713-x. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The patient reached remission again after hydroxyurea dose increased to 1500 mg per day.
Xavier Guillot, Marius Moldovan, Claire Vidon, Daniel Wendling 2014, 'Myelofibrosis-Related Arthritis Successfully Treated with Hydroxyurea', Case Reports in Rheumatologyhttp://dx.doi.org/10.1155/2014/869743. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, the glutathione levels were significantly higher in patients taking hydroxyurea than in controls.
Paulo Florentino Teixeira Neto, Romélia Pinheiro Gonçalves, Darcielle Bruna Dias Elias,Cleiton Pinheiro de Araújo, Hemerson Iury Ferreira Magalhães 2011, 'Analysis of oxidative status and biochemical parameters in adult patients with sicklecell anemia treated with hydroxyurea, Ceará, Brazil', Revista Brasileira de Hematologia e Hemoterapiahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000300013. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Several treatments have been proposed such as adrenergic agents, gonadotropin-releasing hormone analogues, diethylstilbestrol, hydroxyurea.
Perla Vicari, Maria Stella Figueiredo 2007, 'Priapismo na doença falciforme Sickle cell priapism', Revista Brasileira de Hematologia e Hemoterapiahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842007000300016. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Severine Landais, Cecilia D'Alterio, D. Leanne Jones 2014, 'Persistent Replicative Stress Alters Polycomb Phenotypes and Tissue Homeostasis inDrosophila melanogaster', Cell Reportshttp://www.sciencedirect.com/science/article/pii/S2211124714002393. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Hydroxyurea use was not associated with changes in organ function over time.
Courtney D Fitzhugh, Matthew M Hsieh, Darlene Allen, Wynona A Coles, Cassie Seamon,Michael Ring, Xiongce Zhao, Caterina P Minniti, Griffin P Rodgers, Alan N Schechter,John F Tisdale, James G Taylor 2015, 'Hydroxyurea-Increased Fetal Hemoglobin Is Associated with Less Organ Damage and LongerSurvival in Adults with Sickle Cell Anemia.', PLoS ONEhttp://europepmc.org/articles/PMC4648496?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Hydroxyurea treatment was not related to leukemic transformation.
Neslihan Andıç, Mustafa Ünübol, Eren Yağcı, Olga Meltem Akay, İrfan Yavaşoğlu, VefkiGürhan Kadıköylü, Ali Zahit Bolaman 2016, 'Clinical Features of 294 Turkish Patients with Chronic Myeloproliferative Neoplasms',Turkish Journal of Hematologyhttp://www.tjh.com.tr/jvi.aspx?pdir=tjh&plng=eng&un=TJH-97992&look4=. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Hydroxyurea has been proven to be an effective treatment for this condition.
Jihane Abou Rahal, Rim S. Ishak, Zaher K. Otrock, Joseph E. Maakaron, Samer Ghosn,Ali T. Taher 2013, 'Successful Management of Hydroxyurea-induced Leg Ulcers in Essential Thrombocythemia:Report of 3 Cases', Turkish Journal of Hematologyhttp://dx.doi.org/10.4274/Tjh.2012.0134. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
After 10 years of treatment, she failed to respond to hydroxyurea.
Nicoletta Masera, Valentina Decimi, Luisa Tavecchia, Marietta Capra, Giovanni Cazzaniga,Andrea Biondi, Giuseppe Masera 2010, 'A case of beta-thalassaemia major resistant to standard treatment', Clinical Management Issueshttps://journals.seedmedicalpublishers.com/index.php/cmi/article/view/531. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)