an amino acid occurring in some proteins, esp collagen. Formula: (OH)C4H7N(COOH)
hydroxyproline in American English
(haɪˌdrɑksəˈproʊˌlin; haɪˌdrɑksəˈproʊlɪn)
noun
a nonessential amino acid, HOC4H7NCOOH, found in connective tissue, esp. collagens
hydroxyproline in American English
(haiˈdrɑksɪˈproulin, -lɪn)
noun
Biochemistry
a nutritionally nonessential amino acid, C5H9NO3, found chiefly in collagen
Word origin
[1900–05; hydroxy- + proline]This word is first recorded in the period 1900–05. Other words that entered Englishat around the same time include: Young Turk, burnout, cathode-ray tube, desensitize, throwawayhydroxy- is a combining form used in the names of chemical compounds in which the hydroxylgroup is present. Other words that use the affix hydroxy- include: hydroxychloroquine, hydroxyketone, hydroxynaphthalene, hydroxyurea, trihydroxy
Examples of 'hydroxyproline' in a sentence
hydroxyproline
Hepatic fibrosis was analyzed by immunohistochemistry and hepatic hydroxyproline content.
Robert eSchierwagen, Sabine eKlein, Diana Julie Leeming, Michaela eGranzow, MetteJuul Nielsen, Tilman eSauerbruch, Aleksander eKrag, Morten A Karlsdal, Morten A Karlsdal,Jonel eTrebicka 2013, 'Serum markers of the extracellular matrix remodelling reflect antifibrotic therapyin bile-duct ligated rats.', Frontiers in Physiologyhttp://journal.frontiersin.org/Journal/10.3389/fphys.2013.00195/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Hydroxyproline content was correlated with morphometric measurements.
M.M. de Souza, L.M. Silva, A.A. Barbosa Jr., I.R. de Oliveira, R. Paraná, Z.A. Andrade 2000, 'Hepatic capillariasis in rats: a new model for testing antifibrotic drugs', Brazilian Journal of Medical and Biological Researchhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001100011. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Also, levels of hydroxyproline, metalloproteinases and vascular endothelial growth factor were measured.
Alexandre Franca, Fernando Silva Ramalho, Leandra Naira Zambelli Ramalho, José JoaquimRibeiro da Rocha, Omar Féres 2008, 'Effects of preoperative pelvic irradiation on colonic anastomosis healing: an experimentalstudy in rats Efeito da radioterapia pélvica pré-operatória na cicatrização de anastomosescolônicas: estudo experimental em ratos', Acta Cirurgica Brasileirahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502008000700005. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Collagen deposition in lung tissue was estimated by measuring hydroxyproline content.
Hong Mei Piao, Kohei Yamauchi, Li-Hua Pan, Toshihide Nakadate, Harumasa Ito, TakashiMouri, Hitoshi Kobayashi, Takashi Sawai, Tohru Nakanishi, Masaharu Takigawa, HiroshiInoue 2005, 'Increased Levels of CTGF mRNA Expression in a Murine Model of Allergic Airway Inflammation',Allergology Internationalhttp://www.sciencedirect.com/science/article/pii/S1323893015310121. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Biomechanical tensile testing was performed, and collagen content was determined by hydroxyproline quantification.
Oxlund Birgitte S, Ørtoft Gitte, Brüel Annemarie, Danielsen Carl, Oxlund Hans, UldbjergNiels 2010, 'Cervical collagen and biomechanical strength in non-pregnant women with a historyof cervical insufficiency', Reproductive Biology and Endocrinologyhttp://www.rbej.com/content/8/1/92. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Fibrosis was scored and quantified using digital image analysis and hepatic tissue hydroxyproline estimated.
Ameet Dhar, Fouzia Sadiq, Quentin M. Anstee, Adam P. Levene, Robert D. Goldin, MarkR. Thursz 2018, 'Thrombin and factor Xa link the coagulation system with liver fibrosis', BMC Gastroenterologyhttp://link.springer.com/article/10.1186/s12876-018-0789-8. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The tissue-repair effects were also confirmed by hydroxyproline content analysis.
Shao-Yu Peng, Chih-Jen Chou, Po-Jen Cheng, I-Chen Ko, Yi-Jung Kao, Yu-Hsu Chen, WinstonTeng-Kui Cheng, S.W. Steven Shaw, Shinn-Chih Wu 2014, 'Therapeutic potential of amniotic-fluid-derived stem cells on liver fibrosis modelin mice', Taiwanese Journal of Obstetrics & Gynecologyhttp://www.sciencedirect.com/science/article/pii/S102845591400062X. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Fibrosis was assessed from the spectrophotometric determination of tissue hydroxyproline.
Peeters Theo, Depoortere Inge, Vrolix Gunther, Chatterjee Shyama, Van Marck Eric 2005, 'The therapeutic effect of the neuropeptide hormone somatostatin on Schistosomamansoni caused liver fibrosis', BMC Infectious Diseaseshttp://www.biomedcentral.com/1471-2334/5/45. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)