a colourless odourless crystalline compound present in beet molasses: used in the manufacture of pharmaceuticals and synthetic resins. Formula: C3H4N2O2
Word origin
C20: from hyd(rogen + all)antoin product occurring in allantoic fluid
hydantoin in American English
(haiˈdæntouɪn)
noun
Pharmacology
a colorless, needlelike, crystalline compound, C3H4N2O2, used in the synthesis of pharmaceutical substances and resins
Word origin
[1865–70; hyd(rogen) + (all)antoin]This word is first recorded in the period 1865–70. Other words that entered Englishat around the same time include: black belt, dunk, goulash, springboard, valence
Examples of 'hydantoin' in a sentence
hydantoin
The mechanism and selectivity of a bicyclic hydantoin formation by selenium-induced cyclization are investigated.
Biljana M. Šmit, Radoslav Z. Pavlović, Dejan A. Milenković, Zoran S. Marković 2015, 'Mechanism, kinetics and selectivity of selenocyclization of 5-alkenylhydantoins: anexperimental and computational study', Beilstein Journal of Organic Chemistryhttps://doi.org/10.3762/bjoc.11.200. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The thiohydantoin derivatives were less active than their hydantoin congeners.
Ashraf H. Abadi, Jochen Lehmann, Gary A. Piazza, Mohammad Abdel-Halim, Mohamed S.M. Ali 2011, 'Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-β-CarbolineHydantoin and Tetrahydro-β-Carboline Thiohydantoin Derivatives as Phosphodiesterase5 Inhibitors', International Journal of Medicinal Chemistryhttp://dx.doi.org/10.1155/2011/562421. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Barbiturates, hydantoin, primidone and trimethadione were administered to the patients, isolated or in association.
Luís Marques-Assis 1969, 'Considerações a propósito do tratamento medicamentoso de 1217 pacientes epilépticos:I: estudo em relação ao tipo de epilepsia e ao eletrencefalograma Drug treatment of1.211 epileptic patients: I — study regarding the clinical manifestations and eletroencephalographicpatterns', Arquivos de Neuro-Psiquiatriahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1969000400008. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Reactions to obtain hydantoin derivatives were carried out with 5,5-dimethylhydantoin and short-chainaldehydes.
Darci C. Pires, Denise V. B. Stockler-Pinto, Jairo Sciamareli, Jorge Roberto da Costa,Milton Faria Diniz, Koshun Iha, Rita de Cássia L. Dutra 2009, 'Synthesis and characterization by infrared spectroscopy of hydantoin-based bondingagents, used in composite propellants', Journal of Aerospace Technology and Managementhttp://www.jatm.com.br/papers/vol1_n2/JATMv1n2_p177-184_Synthesis_and_characterization_by_infrared_spectroscopy_of_hydantoin-based_bonding_agents_used_in_composite_propellants.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This paper describes different ways of synthesis of hydantoin-derivatives, their physical properties andreactivity.
Trišović Nemanja P., Ušćumlić Gordana S., Petrović Slobodan D. 2009, 'Hydantoins: Synthesis, properties and anticonvulsant activity', Hemijska Industrijahttp://www.doiserbia.nb.rs/img/doi/0367-598X/2009/0367-598X0901017T.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Diphenyl-hydantoin, carbamazepine and valproic acid were the most frequently anticonvulsantsused.
Jazmín Arteaga-Vázquez, Leonora Luna-Muñoz, Osvaldo M Mutchinick 2012, 'Malformaciones congénitas en hijos de madres epilépticas con y sin tratamiento conanticonvulsivantes Congenital malformations in the offspring of epileptic motherswith and without anticonvulsant treatment', Salud Pública de Méxicohttp://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0036-36342012000600006. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Barbiturates, hydantoin, primidone and/or trimethadione were administered.
Luís Marques-Assis 1970, 'Tratamento medicamentoso de 1217 pacientes epilépticos. II: estudo em relação à idadede início, ao tempo de doença e à freqüência das crises Drug treatment of 1217 epilepticpatients. II — A study regarding the age of onset, the disease duration and the frequencyof seizures', Arquivos de Neuro-Psiquiatriahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1970000100005. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The remaining l-hydantoins are racemized by the second enzyme, hydantoin racemase, and continue supplying substrate d-hydantoins to the first enzyme.
María José Rodríguez-Alonso, Felipe Rodríguez-Vico, Francisco Javier Las Heras-Vázquez,Josefa María Clemente-Jiménez 2017, 'l-Amino Acid Production by a Immobilized Double-Racemase Hydantoinase Process: Improvementand Comparison with a Free Protein System', Catalystshttp://www.mdpi.com/2073-4344/7/6/192. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)