In all mammals, the adult liver shows binucleated as well as mononucleated polyploid hepatocytes.
Marco De Santis Puzzonia, Angela Maria Cozzolino, Germana Grassi, Francesca Bisceglia,Raffaele Strippoli, Giulia Guarguaglini, Franca Citarella, Benedetto Sacchetti, MarcoTripodi, Alessandra Marchetti, Laura Amicone 2016, 'TGFbeta Induces Binucleation/Polyploidization in Hepatocytes through a Src-DependentCytokinesis Failure', PLOS ONE10.1371/journal.pone.0167158. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Chromosome aberrations observed include chromosome fragments, chromosome bridges, binucleated cells, and micronucleated cells.
J. I. Raji, C. K. Onwuamah, P. G. C. Odeigah 2018, 'Artemisinin-Based Combination Therapy Depressed Mitosis and Induced Chromosome Aberrationin Onion Root Cells', Journal of Toxicologyhttp://dx.doi.org/10.1155/2018/4671326. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We demonstrate that centriole amplification can induce multipolar anaphase, resulting in binucleated cells.
Edo Dzafic, Paulina J. Strzyz, Michaela Wilsch-Bräuninger, Caren Norden 2015, 'Centriole Amplification in Zebrafish Affects Proliferation and Survival but Not Differentiationof Neural Progenitor Cells', Cell Reportshttp://www.sciencedirect.com/science/article/pii/S2211124715009596. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
83.3% of the nests had one nucleus and 16.7% were binucleated.
Hipólito de Oliveira Almeida, Vicente de Paula Antunes Teixeira, Marlene Antonia dosReis, José Umberto Franciscon, Elizabeth Martins 1987, 'Modificações nucleares em células parasitadas pelo Trypanosoma cruzi em chagásicoscrônicos', Revista da Sociedade Brasileira de Medicina Tropicalhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821987000300004. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Furthermore, we observed an increased proportion of nucleomegaly and binucleated hepatocytes.
Leticia Riverón-Negrete, Gloria Sicilia-Argumedo, Carolina Álvarez-Delgado, ElviaCoballase-Urrutia, Jonathan Alcántar-Fernández, Cristina Fernandez-Mejia 2016, 'Dietary Biotin Supplementation Modifies Hepatic Morphology without Changes in LiverToxicity Markers', BioMed Research Internationalhttp://dx.doi.org/10.1155/2016/7276463. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Pleural cytology revealed numerous plasma cells, some of which were binucleated and atypical.
Dhingra Kajal, Singhal Niti, Nigam Sonu, Jain Shayama 2007, 'Unsuspected multiples myeloma presenting as bilateral pleural effusion – a cytologicaldiagnosis', CytoJournalhttp://www.cytojournal.com/content/4/1/17. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, a portion of the cells instead lost the constriction and became binucleated.
Rajesh Kumar Gupta, Staffan Johansson 2013, 'Fibronectin assembly in the crypts of cytokinesis-blocked multilobular cells promotesanchorage-independent growth.', PLoS ONEhttp://europepmc.org/articles/PMC3741384?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Occasional binucleated and multinucleated tumor giant cells were also noted.
Santosh Kumar Mondal, Palash Kumar Mondal, Sujit Kumar Dutta 2014, 'Cytodiagnosis of epithelioid malignant melanoma (amelanotic) and diagnostic dilemmas',Journal of Cytologyhttp://www.jcytol.org/article.asp?issn=0970-9371;year=2014;volume=31;issue=4;spage=207;epage=209;aulast=Mondal. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The frequency of micronuclei in binucleated cells showed a dose-dependent increase.
Ravindra M Samarth, Tooba Khan, Shweta Srivas, Pradyumna K Mishra, Rajnarayan R Tiwari 2018, 'Evaluation of cyclophosphamide-induced genotoxicity and cytotoxicity in cultured humanlymphocytes', Journal of Radiation and Cancer Researchhttp://www.journalrcr.org/article.asp?issn=0973-0168;year=2018;volume=9;issue=1;spage=28;epage=32;aulast=Samarth. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
All three inhibitors produced a positive response when tested in binucleated cells.
Eloir D. Lourenço, Viviane S. do Amaral, Mauricio Lehmann, Rafael R. Dihl, VirginiaM. Schmitt, Kênya S. Cunha, Maria L. Reguly, Heloisa H.R. de Andrade 2010, 'Micronuclei induced by reverse transcriptase inhibitors in mononucleated and binucleatedcells as assessed by the cytokinesis-block micronucleus assay', Genetics and Molecular Biologyhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000400024. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)