None of these measures of homozygosity was associated with survival to old age.
Maris Kuningas, Ruth McQuillan, James F. Wilson, Albert Hofman, Cornelia M. van Duijn,André G. Uitterlinden, Henning Tiemeier 2011, 'Runs of Homozygosity Do Not Influence Survival to Old Age', PLoS ONE10.1371/journal.pone.0022580. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Hence, we employed homozygosity mapping and linkage analysis.
Takashi Hirano, Naohiko Kobayashi, Tamako Matsuhashi, Daisaku Watanabe, Toshio Watanabe,Akiko Takasuga, Mayumi Sugimoto, Yoshikazu Sugimoto 2013, 'Mapping and exome sequencing identifies a mutation in the IARS gene as the cause ofhereditary perinatal weak calf syndrome.', PLoS ONEhttp://europepmc.org/articles/PMC3660308?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Homozygosity mapping data was available for five cases.
Galuh D. N. Astuti, L. Ingeborgh van den Born, M. Imran Khan, Christian P. Hamel,Béatrice Bocquet, Gaël Manes, Mathieu Quinodoz, Manir Ali, Carmel Toomes, Martin McKibbin,Mohammed E. El-Asrag, Lonneke Haer-Wigman, Chris F. Inglehearn, Graeme C. M. Black,Carel B. Hoyng, Frans P. M. Cremers, Susanne Roosing 2018, 'Identification of Inherited Retinal Disease-Associated Genetic Variants in 11 CandidateGenes', Geneshttp://www.mdpi.com/2073-4425/9/1/21. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Homozygosity mapping revealed the homozygous region including the variant and confirmation of autosomal recessive inheritance.
Kei Mizobuchi, Satoshi Katagiri, Takaaki Hayashi, Kazutoshi Yoshitake, Kaoru Fujinami,Kazuki Kuniyoshi, Reimi Mishima, Kazushige Tsunoda, Takeshi Iwata, Tadashi Nakano 2019, 'Clinical findings of end-stage retinitis pigmentosa with a homozygous PDE6A variant(p.R653X)', American Journal of Ophthalmology Case Reportshttp://www.sciencedirect.com/science/article/pii/S2451993618300793. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Homozygosity of upstream markers caused the recombination indistinguishable.
Mona Entezam, Mohammad Reza Khatami, Fereshteh Saddadi, Mohsen Ayati, Jamshid Roozbeh,Mohammad Keramatipour 2016, 'PKD2 mutation in an Iranian autosomal dominant polycystic kidney disease family withmisleading linkage analysis data', Kidney Research and Clinical Practicehttp://www.sciencedirect.com/science/article/pii/S2211913215300875. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
No homozygosity was found in the study group.
Paulo Roberto de Melo-Reis, Paulo Cesar Naoum, José Alexandre Felizola Diniz-Filho,Karlla Greick Batista Dias-Penna, Mauro Meira de Mesquita, Fernando Amorim Balestra,Yves Mauro Fernandes Ternes, Cíntia do Couto Mascarenhas, Lee Chen Chen 2006, 'Prevalência de talassemias e hemoglobinas variantes no estado de Goiás, Brasil Prevalenceof thalassemias and variant hemoglobins in the state of Goiás, Brazil', Jornal Brasileiro de Patologia e Medicina Laboratorialhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442006000600004. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The homozygosity rate of the loci makes 20; 40 and 30%.
Manvel BADALYAN, Gayane Marmaryan, Yuri MARMARYAN 2018, 'Polymorphism of Blood Serum Protein- Transferrin, Ceruloplasmin, Albumin- in Sheepof Karabakh Breed and the Relationship with the Natural Resistance Towards EpizooticAphtae', Scientific Papers Animal Science and Biotechnologieshttp://spasb.ro/index.php/spasb/article/view/2465. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Both mutations were located within regions of homozygosity shared only among affected individuals.
Robina Khan Niazi, Anette P Gjesing, Mette Hollensted, Christian Theil Have, NielsGrarup, Oluf Pedersen, Asmat Ullah, Gulbin Shahid, Wasim Ahmad, Asma Gul, Torben Hansen 2018, 'Identification of novel LEPR mutations in Pakistani families with morbid childhoodobesity', BMC Medical Geneticshttp://link.springer.com/article/10.1186/s12881-018-0710-x. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Due to the emergence of off-types, homozygosity will be affected.
L.H.M.Y.K. SOMARATNE, A.S.M.T. ABAYAWICKRAMA, I.P. WICKRAMASINGHE, W.L.G. SAMARASINGHE 2012, 'Estimating Out-Crossing Rate of Bg 379-2 Using Morphological Markers and Confirmationby Molecular Markers', Rice Sciencehttp://www.sciencedirect.com/science/article/pii/S1672630812600365. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, levels of homozygosity and inbreeding depression were not reduced.
Tara N. Furstenau, Reed A. Cartwright 2017, 'The impact of self-incompatibility systems on the prevention of biparental inbreeding',PeerJhttps://peerj.com/articles/4085.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)