(ˌtjuːmərɪdʒəˈnɪsɪtɪ) or tumorgenicity (ˌtjuːmədʒəˈnɪsɪtɪ)
noun medicine
1.
the tumorigenic quality of something
2.
the ability or tendency to produce or develop tumours
Examples of 'tumorigenicity' in a sentence
tumorigenicity
Soft agar assay was employed to determine the tumorigenicity.
Xiaoping Ma, Wentian Shi, Lina Peng, Xuying Qin, Yuzuo Hui 2018, 'MiR-96 enhances cellular proliferation and tumorigenicity of human cervical carcinomacells through PTPN9', Saudi Journal of Biological Scienceshttp://www.sciencedirect.com/science/article/pii/S1319562X17302693. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Tumorigenicity was also hampered after secondary transplantation.
Andrew Sulaiman, Sarah McGarry, Li Li, Deyong Jia, Sarah Ooi, Christina Addison, JimDimitroulakos, Angel Arnaout, Carolyn Nessim, Zemin Yao, Guang Ji, Haiyan Song, SureshGadde, Xuguang Li, Lisheng Wang 2018, 'Dual inhibition of Wnt and Yes‐associated protein signaling retards the growth oftriple‐negative breast cancer in both mesenchymal and epithelial states', Molecular Oncologyhttps://doi.org/10.1002/1878-0261.12167. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Likewise, tumorigenicity was significantly inhibited due to reduced levels of proliferation and angiogenesis.
Robert C. Fisher, Kishan Bellamkonda, L. Alex Molina, Shao Xiang, David Liska, SamanehK. Sarvestani, Susmita Chakrabarti, Annamarie Berg, Marda L. Jorgensen, Denise Hatala,Sugong Chen, Alexandra Aiello, Henry D. Appelman, Edward W. Scott, Emina H. Huang 2019, 'Disrupting Inflammation-Associated CXCL8-CXCR1 Signaling Inhibits Tumorigenicity Initiatedby Sporadic- and Colitis-Colon Cancer Stem Cells', Neoplasia: An International Journal for Oncology Researchhttp://www.sciencedirect.com/science/article/pii/S1476558618305931. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Cellular metabolism can change the potency of a chemical's tumorigenicity.
Xiaoqing Rong-Mullins, Michael C. Ayers, Mahmoud Summers, Jennifer E. G. Gallagher 2018, 'Transcriptional Profiling of Saccharomyces cerevisiae Reveals the Impact of Variationof a Single Transcription Factor on Differential Gene Expression in 4NQO, Fermentable,and Nonfermentable Carbon Sources', G3: Genes, Genomes, Geneticshttp://g3journal.org/lookup/doi/10.1534/g3.117.300138. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Suppression of tumorigenicity was also confirmed in vivo.
Hai-long Ma, Shu-fang Jin, Wu-tong Ju, Yong Fu, Yao-yao Tu, Li-zhen Wang, Jiang-Li,Zhi-yuan Zhang, Lai-ping Zhong 2017, 'Stathmin is overexpressed and regulated by mutant p53 in oral squamous cell carcinoma',Journal of Experimental & Clinical Cancer Researchhttp://link.springer.com/article/10.1186/s13046-017-0575-4. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Surface markers, stemness genes, and tumorigenicity were used to test stem properties.
Yu-Chi Wang, Tai-Kuang Chao, Cheng-Chang Chang, Yi-Te Yo, Mu-Hsien Yu, Hung-ChengLai 2013, 'Drug screening identifies niclosamide as an inhibitor of breast cancer stem-like cells.',PLoS ONEhttp://europepmc.org/articles/PMC3776833?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, the biological characteristics and the tumorigenicity of spheres are unknown.
Ying-fei Li, Bing Xiao, San-fang Tu, Yuan-yuan Wang, Xiao-lang Zhang 2012, 'Cultivation and identification of colon cancer stem cell-derived spheres from theColo205 cell line', Brazilian Journal of Medical and Biological Researchhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000300003&lng=en&tlng=en. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, its role in tumorigenicity or metastasis has not been reported.
Junyong Weng, Jingbo Xiao, Yushuai Mi, Xu Fang, Yahuang Sun, Shanbao Li, Zhiwei Qin,Xu Li, Tingting Liu, Senlin Zhao, Lisheng Zhou, Yugang Wen 2018, 'PCDHGA9 acts as a tumor suppressor to induce tumor cell apoptosis and autophagy andinhibit the EMT process in human gastric cancer', Cell Death and Diseasehttp://link.springer.com/article/10.1038/s41419-017-0189-y. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Mutation of transmembrane dimerization motifs, in contrast, significantly reduced anchorage independent growth and tumorigenicity.
Erica L Lawson, David R Mills, Kate E Brilliant, Douglas C Hixson 2012, 'The transmembrane domain of CEACAM1-4S is a determinant of anchorage independent growthand tumorigenicity.', PLoS ONEhttp://europepmc.org/articles/PMC3250453?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)