[1940–45; tumor + -i- + -genic]This word is first recorded in the period 1940–45. Other words that entered Englishat around the same time include: blockbuster, sealant, snorkel, whiteout, zap-i- is the typical ending of the first element of compounds of Latin words, as -o- is of Greek words, but often used in English with a first element of any origin,if the second element is of Latin origin. Other words that use the affix -i- include: Frenchify, cuneiform; -genic is a combining form often corresponding to nouns ending in -gen or -geny, with the following senses: “producing or causing” (hallucinogenic); “produced or caused by” (cosmogenic); “pertaining to a gene or genes” (polygenic); “pertaining to suitability for reproduction by a medium” (telegenic)
Examples of 'tumorigenic' in a sentence
tumorigenic
L1 insertions can contribute to genome plasticity and cause potentially tumorigenic genomic instability.
Barun Pradhan, Tatiana Cajuso, Riku Katainen, Päivi Sulo, Tomas Tanskanen, Outi Kilpivaara,Esa Pitkänen, Lauri A. Aaltonen, Liisa Kauppi, Kimmo Palin 2017, 'Detection of subclonal L1 transductions in colorectal cancer by long-distance inverse-PCRand Nanopore sequencing', Scientific Reportshttp://link.springer.com/article/10.1038/s41598-017-15076-3. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, cells showed a tumorigenic propensity when injected into recipient embryos.
Aurélie Fuet, Guillaume Montillet, Christian Jean, Pauline Aubel, Clémence Kress,Sylvie Rival-Gervier, Bertrand Pain 2018, 'NANOG Is Required for the Long-Term Establishment of Avian Somatic Reprogrammed Cells',Stem Cell Reportshttp://www.sciencedirect.com/science/article/pii/S2213671118303904. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, questions remain regarding the tumorigenic potential of such cells.
Hoshimi Kanemura, Masahiro J. Go, Masayuki Shikamura, Naoki Nishishita, Noriko Sakai,Hiroyuki Kamao, Michiko Mandai, Chikako Morinaga, Masayo Takahashi, Shin Kawamata 2014, 'Tumorigenicity Studies of Induced Pluripotent Stem Cell (iPSC)-Derived Retinal PigmentEpithelium (RPE) for the Treatment of Age-Related Macular Degeneration', PLoS ONE10.1371/journal.pone.0085336. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Prolonged oxidative stress favors tumorigenic environment and inflammation.
Raghavendra S. Patwardhan, Rahul Checker, Deepak Sharma, Santosh K. Sandur, KrishnaB. Sainis 2013, 'Involvement of ERK-Nrf-2 Signaling in Ionizing Radiation Induced Cell Death in Normaland Tumor Cells', PLoS ONE10.1371/journal.pone.0065929. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Similar results were found for human tumorigenic epithelial carcinoma cells.
Karen M. Bussard, Gilbert H. Smith 2011, 'The Mammary Gland Microenvironment Directs Progenitor Cell Fate In Vivo', International Journal of Cell Biologyhttp://dx.doi.org/10.1155/2011/451676. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
They are a group of lipophillic plant compounds with tumorigenic and antitumorigeniceffects.
Masumeh Sanaei, Fraidoon Kavoosi, Mohammad Pourahmadi, Seyede Nasibeh Moosavi 2017, 'Effect of Genistein and 17-β Estradiol on the Viability and Apoptosis of Human HepatocellularCarcinoma HepG2 cell line', Advanced Biomedical Researchhttp://www.advbiores.net/article.asp?issn=2277-9175;year=2017;volume=6;issue=1;spage=163;epage=163;aulast=Sanaei. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Fifty-three gene candidates were found to exhibit effects in all tumorigenic cell lines tested.
Geetika Sethi, Harsh B Pathak, Hong Zhang, Yan Zhou, Margret B Einarson, Vinod Vathipadiekal,Sumedha Gunewardena, Michael J Birrer, Andrew K Godwin 2012, 'An RNA interference lethality screen of the human druggable genome to identify molecularvulnerabilities in epithelial ovarian cancer.', PLoS ONEhttp://europepmc.org/articles/PMC3467214?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Aberrant glycosylation patterns on cancer cells promote several pro-tumorigenic functions, including enhancing tumor cell proliferation.
Jenna Geddes Sweeney, Jennifer Liang, Aristotelis Antonopoulos, Nicholas Giovannone,Shuli Kang, Tony S. Mondala, Steven R. Head, Sandra L. King, Yoshihiko Tani, DanielleBrackett, Anne Dell, George F. Murphy, Stuart M. Haslam, Hans R. Widlund, CharlesJ. Dimitroff 2018, 'Loss of GCNT2/I-branched glycans enhances melanoma growth and survival', Nature Communicationshttp://link.springer.com/article/10.1038/s41467-018-05795-0. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The toxicological predictions suggest no mutagenic, tumorigenic or reproductive effects of the four target molecules.
René Escobedo-González, Claudia Lucia Vargas-Requena, Edgar Moyers-Montoya, Juan ManuelAceves-Hernández, María Inés Nicolás-Vázquez, René Miranda-Ruvalcaba 2017, 'In silico Study of the Pharmacologic Properties and Cytotoxicity Pathways in CancerCells of Various Indolylquinone Analogues of Perezone', Moleculeshttp://www.mdpi.com/1420-3049/22/7/1060. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)