[1945–50; tumor + -i- + -genesis]This word is first recorded in the period 1945–50. Other words that entered Englishat around the same time include: RNA, on-line, poison pill, regression analysis, synchronized swimming-i- is the typical ending of the first element of compounds of Latin words, as -o- is of Greek words, but often used in English with a first element of any origin,if the second element is of Latin origin. Other words that use the affix -i- include: Frenchify, cuneiform
Examples of 'tumorigenesis' in a sentence
tumorigenesis
Xenograft tumorigenesis assay was performed to monitor tumor formation in vivo.
Feiyu Chen, Na Luo, Yu Hu, Xin Li, Kejing Zhang 2018, 'MiR-137 Suppresses Triple-Negative Breast Cancer Stemness and Tumorigenesis by PerturbingBCL11A-DNMT1 Interaction', Cellular Physiology and Biochemistryhttps://www.karger.com/Article/FullText/491526. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Finally, in vivo tumorigenesis studies were used to demonstrate subcutaneous tumor growth.
Guowei Zhang, Hao Zheng, Guojun Zhang, Ruirui Cheng, Chunya Lu, Yijie Guo, GuoqiangZhao 2017, 'MicroRNA-338-3p suppresses cell proliferation and induces apoptosis of non-small-celllung cancer by targeting sphingosine kinase 2', Cancer Cell Internationalhttp://link.springer.com/article/10.1186/s12935-017-0415-9. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Myofibroblasts play important roles in inflammation, fibrosis and tumorigenesis in chronically inflamed liver.
Norifumi eKawada 2015, 'Cytoglobin as a Marker of Hepatic Stellate Cell-derived Myofibroblasts', Frontiers in Physiologyhttp://journal.frontiersin.org/Journal/10.3389/fphys.2015.00329/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These cells are expanded in the early stages of lung tumorigenesis.
Edwige Voisset, Feride Oeztuerk-Winder, Edgar-Josue Ruiz, Juan-Jose Ventura 2013, 'p38α negatively regulates survival and malignant selection of transformed bronchioalveolarstem cells.', PLoS ONEhttp://europepmc.org/articles/PMC3827089?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The results were validated in the tumorigenesis model.
Xian-Jun Sun, Bing-Yan Liu, Shuo Yan, Ting-Hui Jiang, Hui-Qin Cheng, Hao-Sheng Jiang,Yan Cao, Ai-Wu Mao 2015, 'MicroRNA-29a Promotes Pancreatic Cancer Growth by Inhibiting Tristetraprolin', Cellular Physiology and Biochemistryhttp://www.karger.com/Article/FullText/430389. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Inflammation plays an important role in promoting ovarian tumorigenesis and cancer progression.
Zhi-Hui Lu, Xi-Juan Gu, Ke-Zhi Shi, Xuan Li, Dian-Dian Chen, Li Chen 2016, 'Association between genetic polymorphisms of inflammatory response genes and the riskof ovarian cancer', Journal of the Formosan Medical Associationhttp://www.sciencedirect.com/science/article/pii/S0929664615000297. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, the molecular mechanisms responsible for its tumorigenesis and progression remain largely unknown.
Xiabin Lan, Jiajie Xu, Chao Chen, Chuanming Zheng, Jiafeng Wang, Jun Cao, Xuhang Zhu,Minghua Ge 2018, 'The Landscape of Circular RNA Expression Profiles in Papillary Thyroid Carcinoma Basedon RNA Sequencing', Cellular Physiology and Biochemistryhttps://www.karger.com/Article/FullText/490188. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Its up-regulation during tumorigenesis makes this receptor an interesting therapeutic target.
Carolina Otero, Max Linke, Paula Sanchez, Alfonso González, Iwan A. T. Schaap 2013, 'Propranolol Restricts the Mobility of Single EGF-Receptors on the Cell Surface beforeTheir Internalization', PLoS ONE10.1371/journal.pone.0083086. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Four cancer hallmarks are integrated into the model to reflect different developmental aspects of tumorigenesis.
Jian Li, Ulrich R Mansmann 2013, 'Modeling of non-steroidal anti-inflammatory drug effect within signaling pathwaysand miRNA-regulation pathways.', PLoS ONEhttp://europepmc.org/articles/PMC3743815?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Its deregulation compromises tissue homeostasis and contributes to tumorigenesis and other diseases.
Yen-Chi Wu, Kyu-Sun Lee, Yan Song, Stephan Gehrke, Bingwei Lu 2017, 'The bantam microRNA acts through Numb to exert cell growth control and feedback regulationof Notch in tumor-forming stem cells in the Drosophila brain.', PLoS Geneticshttp://europepmc.org/articles/PMC5453605?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)