Jeffrey M. Gidday 2015, 'Extending Injury- and Disease-Resistant CNS Phenotypes by Repetitive Epigenetic Conditioning',Frontiers in Neurologyhttp://journal.frontiersin.org/Journal/10.3389/fneur.2015.00042/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In contrast, putrescine improved recovery in postischemic hearts without exposure to cardioplegic solution.
Andreas Boening, Tim Attmann, Martina Heep, Bernd Niemann, Philippe Grieshaber, RolfSchreckenberg, Klaus-Dieter Schlueter 2017, 'Cardiac surgery with crystalloid cardioplegia: Improved functional recovery due tomolecular adaptations in adult rat hearts', Research in Cardiovascular Medicinehttp://www.rcvmonline.com/article.asp?issn=2251-9572;year=2017;volume=6;issue=4;spage=45;epage=49;aulast=Boening. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Locomotion was video recorded before the insult and at postischemic days 7 and 28.
Iwa Antonow-Schlorke, Julia Ehrhardt, Marcel Knieling 2013, 'Modification of the Ladder Rung Walking Task—New Options for Analysis of Skilled Movements',Stroke Research and Treatmenthttp://dx.doi.org/10.1155/2013/418627. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Both inflammation and microvasculopathy are particularly important in terms of postischemic kidney repair.
Daniel Patschan, S. Patschan, G. A. Müller 2012, 'Inflammation and Microvasculopathy in Renal Ischemia Reperfusion Injury', Journal of Transplantationhttp://dx.doi.org/10.1155/2012/764154. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Tissue protection was associated with increased postischemic angiogenesis and muscle regeneration.
Nicolas Bréchot, Elisa Gomez, Marine Bignon, Jamila Khallou-Laschet, Michael Dussiot,Aurélie Cazes, Cécile Alanio-Bréchot, Mélanie Durand, Josette Philippe, Jean-SébastienSilvestre, Nico Van Rooijen, Pierre Corvol, Antonino Nicoletti, Bénédicte Chazaud,Stéphane Germain 2008, 'Modulation of macrophage activation state protects tissue from necrosis during criticallimb ischemia in thrombospondin-1-deficient mice.', PLoS ONEhttp://europepmc.org/articles/PMC2597179?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Therefore, examining ways to control cell apoptosis has important clinical significance for improving postischemic recovery.
Liang Ge, Yin Cai, Fan Ying, Hao Liu, Dengwen Zhang, Yanjing He, Lei Pang, Dan Yan,Aimin Xu, Haichun Ma, Zhengyuan Xia 2019, 'miR-181c-5p Exacerbates Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis viaTargeting PTPN4', Oxidative Medicine and Cellular Longevityhttp://dx.doi.org/10.1155/2019/1957920. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In conclusion, we observed in the postischemic kidney a marked proliferation of interstitial cells that underwent transient phenotypical modifications.
David Vansthertem, Annabel Gossiaux, Anne-Emilie Declèves, Nathalie Caron, Denis Nonclercq,Alexandre Legrand, Gérard Toubeau 2010, 'Expression of Nestin, Vimentin, and NCAM by Renal Interstitial Cells after IschemicTubular Injury', Journal of Biomedicine and Biotechnologyhttp://dx.doi.org/10.1155/2010/193259. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Postischemic reflow can be restored by systemic administration of either mature endothelial cells or of endothelial progenitor cells.
D. Patschan, S. Patschan, G. A. Müller 2011, 'Endothelial Progenitor Cells in Acute Ischemic Kidney Injury: Strategies for Increasingthe Cells' Renoprotective Competence', International Journal of Nephrologyhttp://dx.doi.org/10.4061/2011/828369. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Early diabetic hearts exhibited reduced carnitine-palmitoyl-transferase-1 activity, but palmitoylcarnitine couldnot rescue protection and enhance postischemic functional recovery.
Phing-How Lou, Eliana Lucchinetti, Liyan Zhang, Andreas Affolter, Manoj Gandhi, MartinHersberger, Blair E Warren, Hélène Lemieux, Hany F Sobhi, Alexander S Clanachan, MichaelZaugg 2014, 'Loss of Intralipid®- but not sevoflurane-mediated cardioprotection in early type-2diabetic hearts of fructose-fed rats: importance of ROS signaling.', PLoS ONEhttp://europepmc.org/articles/PMC4134246?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)