an enzyme that catalyses the transfer of phosphate from ATP to glucose
hexokinase in American English
(ˌheksəˈkaineis, -neiz)
noun
Biochemistry
an enzyme that catalyzes the phosphorylation of hexose sugars
Word origin
[1925–30; hexo(se) + kinase]This word is first recorded in the period 1925–30. Other words that entered Englishat around the same time include: buildup, distinctive feature, gimmick, off-line, turnaround
Examples of 'hexokinase' in a sentence
hexokinase
Secretion of parasite hexokinase and α/β-hydrolase was confirmed by immunofluorescence microscopy.
Igor V. Senderskiy, Sergey A. Timofeev, Elena V. Seliverstova, Olga A. Pavlova, ViacheslavV. Dolgikh 2014, 'Secretion of Antonospora (Paranosema) locustae Proteins into Infected Cells Suggestsan Active Role of Microsporidia in the Control of Host Programs and Metabolic Processes',PLoS ONE10.1371/journal.pone.0093585. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The hexokinase (1–4) family of enzymes catalyze the first step of glycolysis.
Manan M. Mehta, Samuel E. Weinberg, Elizabeth M. Steinert, Krishan Chhiba, CarlosAlberto Martinez, Peng Gao, Harris R. Perlman, Paul Bryce, Nissim Hay, Navdeep S.Chandel 2018, 'Hexokinase 2 is dispensable for T cell-dependent immunity', Cancer & Metabolismhttp://link.springer.com/article/10.1186/s40170-018-0184-5. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Hexokinase activity was not affected in brain or liver.
Flavia Letícia Martins Peçanha, Reinaldo Sousa dos Santos, Wagner Seixas da-Silva 2017, 'Thyroid states regulate subcellular glucose phosphorylation activity in male mice',Endocrine Connectionshttp://www.endocrineconnections.com/content/6/5/311.full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Glucose levels were determined using the hexokinase method.
Raja Reddy P, Reethesh RP, Mahesh V 2013, 'The association between estimated average glucose levels and fasting plasma glucoselevels in a rural tertiary care centre', Global Journal of Medicine and Public Healthhttp://www.gjmedph.org/uploads/O5-Vo2No1.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Additionally, functional coupling between hexokinase and mitochondria can be investigated by monitoring the effect of glucose on respiration.
Marju Puurand, Kersti Tepp, Aleksandr Klepinin, Lyudmila Klepinina, Igor Shevchuk,Tuuli Kaambre 2018, 'Intracellular Energy-Transfer Networks and High-Resolution Respirometry: A ConvenientApproach for Studying Their Function', International Journal of Molecular Scienceshttp://www.mdpi.com/1422-0067/19/10/2933. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Glucokinase content and hexokinase specific activity were also the same in the control and hypothyroidgroups.
Aliashraf Godini, Asghar Ghasemi, Saleh Zahediasl 2015, 'The Possible Mechanisms of the Impaired Insulin Secretion in Hypothyroid Rats', PLOS ONE10.1371/journal.pone.0131198. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Sucrose synthase, sucrose-phosphate synthase and hexokinase were all actively upregulatedat both the protein and transcriptional levels.
Yuanyuan Cui, Ziran Wang, Shangwu Chen, Alexander Vainstein, Huiqin Ma 2019, 'Proteome and transcriptome analyses reveal key molecular differences between qualityparameters of commercial-ripe and tree-ripe fig (Ficus carica L.)', BMC Plant Biologyhttp://link.springer.com/article/10.1186/s12870-019-1742-x. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This hexokinase-dependent process seems to be reversed upon the removal of glucose or other hexose sugars.
Maria R. Depaoli, Felix Karsten, Corina T. Madreiter-Sokolowski, Christiane Klec,Benjamin Gottschalk, Helmut Bischof, Emrah Eroglu, Markus Waldeck-Weiermair, ThomasSimmen, Wolfgang F. Graier, Roland Malli 2018, 'Real-Time Imaging of Mitochondrial ATP Dynamics Reveals the Metabolic Setting of SingleCells', Cell Reportshttp://www.sciencedirect.com/science/article/pii/S2211124718314578. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Glucokinase and hexokinase specific activity, glucokinase content, and glucose transporter2 protein expression were also determined in the isolated islets.
Aliashraf Godini, Asghar Ghasemi, Saleh Zahediasl 2015, 'The Possible Mechanisms of the Impaired Insulin Secretion in Hypothyroid Rats.', PLoS ONEhttp://europepmc.org/articles/PMC4488449?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)