Imidazo[2,1-b][1,3,4]thiadiazole heterocycle was discovered during the 1950s.
Bhoomendra A. Bhongade, Sirajunisa Talath, Ravikiran A. Gadad, Andanappa K. Gadad 2016, 'Biological activities of imidazo[2,1-b][1,3,4]thiadiazole derivatives: A review',Journal of Saudi Chemical Societyhttp://www.sciencedirect.com/science/article/pii/S1319610313000136. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Catalyst reusability enabled the synthesis of the heterocycle in moderate yields for four consecutive runs.
Jaqueline D. Senra, Aires C. Silva, Raquel V. Santos, Luiz Fernando B. Malta, AlessandroB. C. Simas 2017, 'Palladium on Layered Double Hydroxide: A Heterogeneous System for the Enol PhosphateCarbon-Oxygen Bond Activation in Aqueous Media', Journal of Chemistryhttp://dx.doi.org/10.1155/2017/8418939. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The six-membered heterocycle of the dihydroisoquinoline unit adopts a half-chair conformation.
Le Zhou, Weigang Hu, Bin Zhu, Fangjun Cao, Yanni Ma 2011, '2-(4-Bromophenyl)-3,4-dihydroisoquinolin-2-ium thiocyanate hemihydrate', Acta Crystallographica Section Ehttp://scripts.iucr.org/cgi-bin/paper?S1600536811038542. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This review outlines the nitrogen heterocycle content of carbonaceous meteorites.
Zita Martins 2018, 'The Nitrogen Heterocycle Content of Meteorites and Their Significance for the Originof Life', Lifehttp://www.mdpi.com/2075-1729/8/3/28. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
One heterocycle binds to a metal center whereas the other bridges two metal centers.
Yousef Fazaeli, Mostafa M. Amini, Seik Weng Ng 2010, 'Bis(μ-2-methyl-8-oxidoquinolin-1-ium-κ2O:O)bis[(acetato-κ2O,O′)(2-methyl-8-oxidoquinolin-1-ium-κO)bis(nitrato-κ2O,O′)lanthanum(III)]',Acta Crystallographica Section Ehttp://scripts.iucr.org/cgi-bin/paper?S1600536809055743. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The methodology was validated in the synthesis of two small heterocycle containing libraries.
Christina M. Thompson, Stevan W. Djuric, Jeffrey L. Cross, Irini Akritopoulou-Zanze,Jennifer L. Poole 2011, 'Small Molecule Library Synthesis Using Segmented Flow', Moleculeshttp://www.mdpi.com/1420-3049/16/11/9161/. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The six-membered heterocycle has a twisted half-chair conformation in both molecules.
Hemant P. Yennawar, Duncan J. Noble, Lee J. Silverberg 2017, 'Crystal structure of (1S,2S,5R)-5-acetylamino-4-oxo-2,3-diphenyl-1,3-thiazinan-1-ium-1-olate',Acta Crystallographica Section E: Crystallographic Communicationshttp://scripts.iucr.org/cgi-bin/paper?S2056989017012488. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The heterocycle assumes a distorted boat conformation.
Egija Stepina, Dmitrijs Stepanovs, Inese Mierina, Mara Jure 2015, 'Crystal structure of 5-[4-(diethylamino)benzylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione',Acta Crystallographica Section E: Crystallographic Communicationshttp://scripts.iucr.org/cgi-bin/paper?S2056989015017673. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)