Delayed hepatotoxicity suggested a dose dependency and a cumulative effect.
Tim Bühler, Michael Medinger, Jamal Bouitbir, Stephan Krähenbühl, Anne Leuppi-Taegtmeyer 2019, 'Hepatotoxicity Due to Azole Antimycotic Agents in a HLA B*35:02-Positive Patient',Frontiers in Pharmacologyhttps://www.frontiersin.org/article/10.3389/fphar.2019.00645/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
A liver biopsy of one man was consistent with khat hepatotoxicity.
Hawa D. Mahamoud, Sabah Mohammed Muse, Lewis R. Roberts, Philip R. Fischer, MichaelS. Torbenson, Tim Fader 2016, 'Khat chewing and cirrhosis in Somaliland: Case series', African Journal of Primary Health Care & Family Medicinehttps://phcfm.org/index.php/phcfm/article/view/1124. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Serum hepatotoxicity markers were determined, and histopathological evaluation was performed.
Hesham M. Mahmoud, Mona Osman, Osama Elshabrawy, Heba M. I. Abdallah, Ahmed Khairallah 2019, 'AM-1241 CB2 Receptor Agonist Attenuates Inflammation, Apoptosis and Stimulate ProgenitorCells in Bile Duct Ligated Rats', Open Access Macedonian Journal of Medical Scienceshttps://www.id-press.eu/mjms/article/view/2786. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The incidence of severe hepatotoxicity was 10.7% (6/56 patients).
Emily L. Heil, Mary L. Townsend, Kenneth Shipp, Amy Clarke, Melissa D. Johnson 2010, 'Incidence of Severe Hepatotoxicity Related to Antiretroviral Therapy in HIV/HCV CoinfectedPatients', AIDS Research and Treatmenthttp://dx.doi.org/10.1155/2010/856542. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These transcription factors are central to alcohol-mediated hepatotoxicity.
Rais A. Ansari, Kazim Husain, Syed A. A. Rizvi 2016, 'Role of Transcription Factors in Steatohepatitis and Hypertension after Ethanol: TheEpicenter of Metabolism', Biomoleculeshttp://www.mdpi.com/2218-273X/6/3/29. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Thorough investigation, including histopathological examination, revealed no other cause of hepatotoxicity.
Y Radha Krishna, V Mittal, P Grewal, MI Fiel, T Schiano 2011, 'Acute Liver Failure Caused by ‘Fat Burners' and Dietary Supplements: A Case Reportand Literature Review', Canadian Journal of Gastroenterologyhttp://dx.doi.org/10.1155/2011/174978. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, intravenous steroids have rarely been associated with hepatotoxicity.
M. Rivero Fernández, J. M. Riesco, V. F. Moreira, A. Moreno, A. López San Román, G.Arranz, L. Ruiz del Árbol 2008, 'Toxicidad hepática recurrente secundaria a metilprednisolona intravenosa Recurrentacute liver toxicity from intravenous methyprednisolone', Revista Espanola de Enfermedades Digestivashttp://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082008001100010. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Oxidative stress has been proven to be involved in cisplatin-induced hepatotoxicity.
Daryoush Mohajeri, Yousef Doustar, Ghafour Mousavi 2012, 'Protective and antioxidant activities of turnip root ethanolic extract against cisplatininduced hepatotoxicity in rats', Majallah-i taḥqīqāt-i ̒ulūm-i pizishkī-i Zāhidānhttp://www.zjrms.ir/browse.php?a_id=1783&sid=1&slc_lang=en. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)