Note, 22 patients reported hepatotoxic co-medications especially during periods of pain.
Nora Anderson, Jürgen Borlak 2019, 'Hepatobiliary Events in Migraine Therapy with Herbs—The Case of Petadolex, A PetasitesHybridus Extract', Journal of Clinical Medicinehttps://www.mdpi.com/2077-0383/8/5/652. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Vanadium also exhibits hepatotoxic and nephrotoxic properties, including glomerulonephritis and pyelonephritis.
Aleksandra Wilk, Dagmara Szypulska-Koziarska, Barbara Wiszniewska 2017, 'The toxicity of vanadium on gastrointestinal, urinary and reproductive system, andits influence on fertility and fetuses malformations', Postępy Higieny i Medycyny Doświadczalnejhttp://phmd.pl/gicid/01.3001.0010.4783. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Reports were classified into hepatotoxic reactions or other reactions.
Kristina Star, I Ralph Edwards, Imti Choonara 2014, 'Valproic acid and fatalities in children: a review of individual case safety reportsin VigiBase.', PLoS ONEhttp://europepmc.org/articles/PMC4193865?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
During this process, hepatotoxic metabolites may be generated causing liver injury in susceptible patients.
Christian Frenzel, Rolf Teschke 2016, 'Herbal Hepatotoxicity: Clinical Characteristics and Listing Compilation', International Journal of Molecular Scienceshttp://www.mdpi.com/1422-0067/17/5/588. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Public health concerns of phthalates include carcinogenic, teratogenic, hepatotoxic and endocrine effects.
Jenny Leitz, Thomas Kuballa, Jürgen Rehm, Dirk W Lachenmeier 2009, 'Chemical analysis and risk assessment of diethyl phthalate in alcoholic beverageswith special regard to unrecorded alcohol.', PLoS ONEhttp://europepmc.org/articles/PMC2779849?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Jesús Rafael Rodriguez Amado, Ariadna Lafourcade Prada, Julio Cesar Escalona Arranz,Renato Pérez Rosés, Humberto Morris Quevedo, Hady Keita, Edgar Puente Zapata, CaioPinho Fernandes, José Carlos Tavares Carvalho 2016, 'Antioxidant and Hepatoprotective Activity of a New Tablets Formulation from Tamarindusindica L.', Evidence-Based Complementary and Alternative Medicinehttp://dx.doi.org/10.1155/2016/3918219. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Finally, the chemical combination of markers was subjected to hepatotoxic equivalence evaluation.
Wei Shi, Cai Zhang, Dongsheng Zhao, Lingli Wang, Ping Li, Huijun Li 2018, 'Discovery of Hepatotoxic Equivalent Combinatorial Markers from Dioscorea bulbiferatuber by Fingerprint-Toxicity Relationship Modeling', Scientific Reportshttp://link.springer.com/article/10.1038/s41598-017-18929-z. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)