containing three groups or atoms introduced into the molecule in place of three original groups or atoms
trisubstituted in American English
(traiˈsʌbstɪˌtuːtɪd, -ˌtjuː-)
adjective
Chemistry
pertaining to a molecule containing three substituents
Word origin
[1895–1900; tri- + substitute + -ed2]This word is first recorded in the period 1895–1900. Other words that entered Englishat around the same time include: Marxism, apothecaries' measure, frame of reference, hit-and-run, neon-ed is a suffix forming the past participle of weak verbs (he had crossed the river), and of participial adjectives indicating a condition or quality resulting fromthe action of the verb (inflated balloons). Other words that use the affix -ed include: connected, frosted, integrated, loaded, unsettled
Examples of 'trisubstituted' in a sentence
trisubstituted
In both molecules, the central 1,3,5-trisubstituted dihydropyrazole ring adopts an envelope conformation.
Kseniya K. Borisova, Flavien A. A. Toze, Nniyaz Z. Yagafarov, Fedor I. Zubkov, PavelV. Dorovatovskii, Yan V. Zubavichus, Victor N. Khrustalev 2016, 'Crystal structures of (5RS)-(Z)-4-[5-(furan-2-yl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]-4-oxobut-2-enoicacid and (5RS)-(Z)-4-[5-(furan-2-yl)-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-oxobut-2-enoicacid', Acta Crystallographica Section E: Crystallographic Communicationshttp://scripts.iucr.org/cgi-bin/paper?S2056989016013992. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The synthesis of 1,2,3-trisubstituted indoles was investigated.
Michael Ghobrial, Marko D. Mihovilovic, Michael Schnürch 2014, 'Exploration of C–H and N–H-bond functionalization towards 1-(1,2-diarylindol-3-yl)tetrahydroisoquinolines',Beilstein Journal of Organic Chemistryhttps://doi.org/10.3762/bjoc.10.226. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Herein, we report the design, synthesis and trypanocidal activity of some novel trisubstituted imidazole derivatives.
Edson Ferreira da Silva, Carlos Alberto Manssour Fraga, Samir Aquino Carvalho, Mariadas Graças Muller Oliveira de Henriques, Carmen Penido, Solange M. S. V. Wardell,Thadeu Estevam Moreira Maramaldo Costa, James L. Wardell, Solange Lisboa de Castro,Kelly Salomão, Ramon Borges da Silva, Vanessa Brandão Loback 2013, 'Article Synthesis and Trypanocidal Activity of Novel 2,4,5-Triaryl-N-HydroxylimidazoleDerivatives', Moleculeshttp://www.mdpi.com/1420-3049/18/3/3445. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The reaction also proceeded smoothly with several other synthetically useful activated trisubstituted olefins.
Wen Ren, Qian Zhao, Chuan Zheng, Qiong Zhao, Li Guo, Wei Huang 2016, 'Efficient Synthesis of Fully Substituted Pyrrolidine-Fused 3-Spirooxindoles via 1,3-DipolarCycloaddition of Aziridine and 3-Ylideneoxindole', Moleculeshttp://www.mdpi.com/1420-3049/21/9/1113. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These esters could be readily hydrolysed into the desired 1,2,3-trisubstituted xylofuranose.
NADA S.VUKOJEVIC, PAVLE A. HADZIC 2001, 'Selective desulfonylation in D-xylofuranose 3,5-disulfonates', Journal of the Serbian Chemical Societyhttp://www.shd.org.yu/HtDocs/SHD/Vol66/No5/v66-no5-01.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This procedure led to the corresponding 2,4,5-trisubstituted imidazoles products in high yields.
M. Alikarami, M. Amozad 2017, 'One-pot synthesis of 2,4,5-trisubstituted imidazole derivatives catalyzed by btppcunder solvent-free conditions', Bulletin of the Chemical Society of Ethiopiahttps://www.ajol.info/index.php/bcse/article/view/158852. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The trimers consist of three triphenylene discotic units linked to a central 1,2,4-trisubstituted benzene ring via flexible spacers.
Bin Han, Ping Hu, Bi-Qin Wang, Carl Redshaw, Ke-Qing Zhao 2013, 'Triphenylene discotic liquid crystal trimers synthesized by Co2(CO)8-catalyzed terminalalkyne [2 + 2 + 2] cycloaddition', Beilstein Journal of Organic Chemistryhttps://doi.org/10.3762/bjoc.9.321. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The trisubstituted benzene ring occupies a position almost perpendicular to the pyran ring [dihedral angle = 83.97 (4)°].
Mukesh M. Jotani, P. Iniyavan, V. Vijayakumar, S. Sarveswari, Yee Seng Tan, EdwardR. T. Tiekink 2016, '12-(3,4,5-Trimethoxyphenyl)-2,3,4,12-tetrahydro-1H-5-oxatetraphen-1-one: crystal structureand Hirshfeld surface analysis', Acta Crystallographica Section E: Crystallographic Communicationshttp://scripts.iucr.org/cgi-bin/paper?S2056989016007775. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We have designed a new sequential carbocupration and sulfur–lithium exchange that leads stereo- and regioselectively to trisubstituted alkenyllithiums.
Andreas Unsinn, Cora Dunst, Paul Knochel 2012, 'Stereoselective synthesis of tetrasubstituted alkenes via a sequential carbocuprationand a new sulfur–lithium exchange', Beilstein Journal of Organic Chemistryhttps://doi.org/10.3762/bjoc.8.248. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The systematic structure-activity relationship of these trisubstituted pyrimidine amide derivatives was discussed based on the obtained experimental data.
Libao Xu, Yang Zhang, Wenjie Dai, Ying Wang, Dan Jiang, Lili Wang, Junhai Xiao, XiaohongYang, Song Li 2014, 'Design, Synthesis and SAR Study of Novel Trisubstituted Pyrimidine Amide Derivativesas CCR4 Antagonists', Moleculeshttp://www.mdpi.com/1420-3049/19/3/3539. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)