the condition of having one chromosome of the set represented three times in an otherwise diploid organism, cell, etc. Trisomy of chromosome 21 results in Down's syndrome
Word origin
C20: from tri- + (chromo)som(e) + -y3
trisomy in American English
(ˈtraisoumi)
noun
Pathology
an abnormality characterized by the presence of an additional chromosome to the normal diploid number
Word origin
[1925–30; tri- + -some3 + -y3]This word is first recorded in the period 1925–30. Other words that entered Englishat around the same time include: chain reaction, gimmick, hot spot, off-line, recycle-y is a suffix of various origins used in the formation of action nouns from verbs (inquiry), also found in other abstract nouns (carpentry; infamy)
Examples of 'trisomy' in a sentence
trisomy
Two of nine samples tested had an abnormal karyotype represented by trisomy 20.
Mader Emily K, Butler Greg, Dowdy Sean C, Mariani Andrea, Knutson Keith L, FederspielMark J, Russell Stephen J, Galanis Evanthia, Dietz Allan B, Peng Kah-Whye 2013, 'Optimizing patient derived mesenchymal stem cells as virus carriers for a Phase Iclinical trial in ovarian cancer', Journal of Translational Medicinehttp://www.translational-medicine.com/content/11/1/20. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We present a rare case of partial trisomy 13q with exclusive clinical manifestations.
Allam Abuhamda, Aymen Elsous, Fadel A. Sharif 2019, 'Partial Trisomy of Chromosome 13 with a Novel Translocation (8 ; 13) and Unique ClinicalPresentation in a Palestinian Infant', Case Reports in Medicinehttp://dx.doi.org/10.1155/2019/4561761. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Furthermore, the karyotyping report revealed trisomy 18.
Tun-Jun Wang, Yi-Ying Li, Wan-Ju Wu, Chi-Kang Lin, Chun-Kai Wang, Chen-Yu Wang, Kwei-ShuaiHwang, Her-Young Su 2017, 'Dandy–Walker syndrome with duplex kidney abnormalities in trisomy 18 – A rare casereport', Taiwanese Journal of Obstetrics & Gynecologyhttp://www.sciencedirect.com/science/article/pii/S1028455917302115. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Cytogenetic analysis revealed variable results (trisomy 9 and deletion 3).
Kotru Mrinalini, Batra Madhu, Gomber Sunil, Rusia Usha 2009, 'Transient thrombocytosis with megathrombocytes in a case of acute myeloblastic leukemia',Indian Journal of Pathology and Microbiologyhttp://www.ijpmonline.org/article.asp?issn=0377-4929;year=2009;volume=52;issue=1;spage=113;epage=114;aulast=Kotru. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Full trisomy of chromosome 13 was the main cytogenetic finding (74%).
Rafael Fabiano M. Rosa, Melina Vaz Sarmento, Janaina Borges Polli, Daniela de PaoliGroff, Patrícia Petry, Vinícius Freitas de Mattos, Rosana Cardoso M. Rosa, PatríciaTrevisan, Paulo Ricardo G. Zen 2013, 'Gestational, perinatal and family findings of patients with Patau syndrome', Revista Paulista de Pediatriahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822013000400459&lng=en&tlng=en. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The trisomy of chromosome 21 has been most evaluated.
Gregório Lorenzo Acácio, Ricardo Barini, Walter Pinto Júnior, Renato Luís SilveiraXimenes, Heverton Pettersen, Marcos Faria 2001, 'Nuchal translucency: an ultrasound marker for fetal chromosomal abnormalities', São Paulo Medical Journalhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802001000100006&lng=en&tlng=en. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These outcomes suggest that altered gene expression in trisomy could elevate a proliferation signalling pathway.
Annan Yang, Duane Currier, Jennifer L Poitras, Roger H Reeves 2016, 'Increased Skin Tumor Incidence and Keratinocyte Hyper-Proliferation in a Mouse Modelof Down Syndrome.', PLoS ONEhttp://europepmc.org/articles/PMC4708994?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
All three trisomy groups showed increased risk of milder symptoms of social anxiety.
Alexander C. Wilson, Judith King, Dorothy V.M. Bishop 2019, 'Autism and social anxiety in children with sex chromosome trisomies: an observationalstudy [version 1; peer review: 2 approved]', Wellcome Open Researchhttps://wellcomeopenresearch.org/articles/4-32/v1. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We report a case of a premature female with trisomy 18 diagnosed by amniocentesis.
Patricia Isabel Delgado, Correa-Medina Correa-Medina, Claudia P. Rojas 2017, 'Pancreatic hamartoma in a premature Trisomy 18 female', Autopsy and Case Reportshttp://www.revistas.usp.br/autopsy/article/view/141470. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
It can be assumed that trisomy 18 potentiates the development of hepatoblastoma.
Kitanovski Lidija, Ovcak Zdenka, Jazbec Janez 2009, 'Multifocal hepatoblastoma in a 6-month-old girl with trisomy 18: a case report', Journal of Medical Case Reportshttp://www.jmedicalcasereports.com/content/3/1/8319. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)