this fragment contains the ccdB gene, which encodes a protein that prevents growthon most E. coli strains by interfering with DNA gyrase
gyrase in American English
(ˈdʒaireis, -reiz)
noun
Biochemistry
a bacterial enzyme that causes supercoiling of DNA
Word origin
[1976; gyr- + -ase]-ase is a suffix used in the names of enzymes. Other words that use the affix -ase include: hyaluronidase, oxidase, phosphorylase, reverse transcriptase, transferase
Examples of 'gyrase' in a sentence
gyrase
Gyrase mutants that caused dramatic supercoil losses also reduced the transcription elongation rates throughout the genome.
Nikolay Rovinskiy, Andrews Akwasi Agbleke, Olga Chesnokova, Zhenhua Pang, N PatrickHiggins 2012, 'Rates of gyrase supercoiling and transcription elongation control supercoil densityin a bacterial chromosome.', PLoS Geneticshttp://europepmc.org/articles/PMC3420936?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Until recently gyrase was thought to be unique to bacteria, but has now been discovered in plants.
Katherine M Evans-Roberts, Christian Breuer, Melisa K Wall, Keiko Sugimoto-Shirasu,Anthony Maxwell 2010, 'Arabidopsis thaliana GYRB3 does not encode a DNA gyrase subunit.', PLoS ONEhttp://europepmc.org/articles/PMC2845627?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Antimicrobial synergy could be detected with levofloxacin and novobiocin, targeting the gyrase enzyme, and with spectinomycin, impeding ribosomal function.
Nadja Patenge, Roberto Pappesch, Franziska Krawack, Claudia Walda, Mobarak Abu Mraheil,Anette Jacob, Torsten Hain, Bernd Kreikemeyer 2013, 'Inhibition of Growth and Gene Expression by PNA-peptide Conjugates in Streptococcuspyogenes', Molecular Therapy: Nucleic Acidshttp://www.sciencedirect.com/science/article/pii/S2162253116301937. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Here, we performed an in-depth analysis of the evolutionary history of reverse gyrase in light of genomic progress.
Céline Brochier-Armanet, Patrick Forterre 2006, 'Widespread distribution of archaeal reverse gyrase in thermophilic bacteria suggestsa complex history of vertical inheritance and lateral gene transfers', Archaeahttp://dx.doi.org/10.1155/2006/582916. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Fluoroquinolone resistance and associated gyrase mutations were frequent in various ribotypes, but no resistance to metronidazole or vancomycin was noted.
Nils Henning Zaiß, Wolfgang Witte, Ulrich Nübel 2010, 'Fluoroquinolone Resistance and Clostridium difficile, Germany', Emerging Infectious Diseaseshttps://wwwnc.cdc.gov/eid/article/16/4/09-0859_article. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)