Significantly increased ovarian cysts were detected after pinealectomy and melatonin did not prevent this increase.
Önder Çelik, Hakan Parlakpınar, Şeyma Hasçalık, Bülent Mızrak, Murat Özşahin 2008, 'Role of Melatonin on Follicle Development and Apoptotic Changes in PinealectomizedRat Ovary', Gormhttp://gorm.com.tr/index.php/GORM/article/view/424. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Daily rhythms of leptin under both long and short photoperiods were blunted by pinealectomy.
Ibtissam eChakir, Ibtissam eChakir, Stephanie eDumont, Ali eOuarour, Paul ePevet,Etienne eChallet, Patrick eVuillez 2015, 'Pineal melatonin is a circadian time-giver for leptin rhythm in Syrian hamsters',Frontiers in Neurosciencehttp://journal.frontiersin.org/Journal/10.3389/fnins.2015.00190/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Furthermore, the phase of cortisol rhythm under a short photoperiod was advanced by 5.6 h after pinealectomy.
Ibtissam eChakir, Ibtissam eChakir, Stephanie eDumont, Ali eOuarour, Paul ePevet,Etienne eChallet, Patrick eVuillez 2015, 'Pineal melatonin is a circadian time-giver for leptin rhythm in Syrian hamsters',Frontiers in Neurosciencehttp://journal.frontiersin.org/Journal/10.3389/fnins.2015.00190/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We conclude that melatonin may act on the ovarian response reverting chronic anovulation induced by pinealectomy or continuous light.
M.F. Prata Lima, E.C. Baracat, M.J. Simões 2004, 'Effects of melatonin on the ovarian response to pinealectomy or continuous light infemale rats: similarity with polycystic ovary syndrome', Brazilian Journal of Medical and Biological Researchhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000700007. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The scoliosis deformity was believed to be induced by pinealectomy and mediated through the resulting melatonin-deficiency.
Man Gene Chi Wai, Wang William Wei Jun, Yim Annie Po Yee, Wong Jack Ho, Ng Tzi Bun,Lam Tsz Ping, Lee Simon Kwong Man, Ng Bobby Kin Wah, Wang Chi Chiu, Qiu Yong, ChengJack Chun Yiu 2014, 'A Review of Pinealectomy-Induced Melatonin-Deficient Animal Models for the Studyof Etiopathogenesis of Adolescent Idiopathic Scoliosis', International Journal of Molecular Scienceshttp://www.mdpi.com/1422-0067/15/9/16484. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Classically, the pineal gland and a pinealectomy were associated with glucose homeostasis even before melatonin was chemically isolated.
Juan C. Mayo, Arturo Aguado, Rafael Cernuda-Cernuda, Alejandro Álvarez-Artime, VanesaCepas, Isabel Quirós-González, David Hevia, Rosa M. Sáinz 2018, 'Melatonin Uptake by Cells: An Answer to Its Relationship with Glucose?', Moleculeshttp://www.mdpi.com/1420-3049/23/8/1999. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)