the process by which sugars are chemically attached to proteins to form glycoproteins
Word origin
from glycosyl radical derived from glycose + -ation
Examples of 'glycosylation' in a sentence
glycosylation
Altered protein glycosylation patterns are associated with most diseases including malignant transformation.
Manveen K. Sethi, Susan Fanayan 2015, 'Mass Spectrometry-Based N-Glycomics of Colorectal Cancer', International Journal of Molecular Scienceshttp://www.mdpi.com/1422-0067/16/12/26165. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
All of the cells are coated by glycosylation complex and thick carbohydrates layer.
Weilin Wang, Xiaorui Song, Lingling Wang, Linsheng Song 2018, 'Pathogen-Derived Carbohydrate Recognition in Molluscs Immune Defense', International Journal of Molecular Scienceshttp://www.mdpi.com/1422-0067/19/3/721. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Ninety-two glycosylation-related genes were expressed in milk somatic cells.
Saumya Wickramasinghe, Serenus Hua, Gonzalo Rincon, Alma Islas-Trejo, J Bruce German,Carlito B Lebrilla, Juan F Medrano 2011, 'Transcriptome profiling of bovine milk oligosaccharide metabolism genes using RNA-sequencing.',PLoS ONEhttp://europepmc.org/articles/PMC3081824?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Glycosylation changes are a feature of disease states.
Leonardo eFreire-de-Lima 2014, 'Sweet and Sour: The Impact of Differential Glycosylation in Cancer Cells UndergoingEpithelial-Mesenchymal Transition', Frontiers in Oncologyhttp://journal.frontiersin.org/Journal/10.3389/fonc.2014.00059/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We have studied its glycosylation as this may distinguish it from renal renin.
Anthony JM Stubbs, Sandford L Skinner 2004, 'Lectin chromatography of extrarenal renin protein in human plasma and tissues: Potentialendocrine function via the renin receptor', Journal of the Renin-Angiotensin-Aldosterone Systemhttps://doi.org/10.3317/jraas.2004.039. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In 7/27 patients the neutral glycosylation-deficient mutant was recognized stronger.
Iris Marti Fernandez, Caterina Macrini, Markus Krumbholz, Paul J. Hensbergen, AgnesL. Hipgrave Ederveen, Stephan Winklmeier, Atay Vural, Atay Vural, Asli Kurne, DieterJenne, Frits Kamp, Lisa Ann Gerdes, Reinhard Hohlfeld, Manfred Wuhrer, Tania Kümpfel,Edgar Meinl 2019, 'The Glycosylation Site of Myelin Oligodendrocyte Glycoprotein Affects AutoantibodyRecognition in a Large Proportion of Patients', Frontiers in Immunologyhttps://www.frontiersin.org/article/10.3389/fimmu.2019.01189/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We noted seven different patterns of recognition of the two glycosylation-deficient mutants by different patients.
Iris Marti Fernandez, Caterina Macrini, Markus Krumbholz, Paul J. Hensbergen, AgnesL. Hipgrave Ederveen, Stephan Winklmeier, Atay Vural, Atay Vural, Asli Kurne, DieterJenne, Frits Kamp, Lisa Ann Gerdes, Reinhard Hohlfeld, Manfred Wuhrer, Tania Kümpfel,Edgar Meinl 2019, 'The Glycosylation Site of Myelin Oligodendrocyte Glycoprotein Affects AutoantibodyRecognition in a Large Proportion of Patients', Frontiers in Immunologyhttps://www.frontiersin.org/article/10.3389/fimmu.2019.01189/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This suggested the involvement of a lipid carrier in glycosylation.
Susana Merino, Kelly M. Fulton, Susan M. Twine, Markus Wilhelms, Raquel Molero, JuanM. Tomás 2014, 'Aeromonas hydrophila Flagella Glycosylation: Involvement of a Lipid Carrier', PLoS ONE10.1371/journal.pone.0089630. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Heterogeneity was also observed for the use of glycosylation sites in the hypervariable region.
Bastian Thaa, Balaji Chandrasekhar Sinhadri, Claudia Tielesch, Eberhard Krause, MichaelVeit 2013, 'Signal Peptide Cleavage from GP5 of PRRSV: A Minor Fraction of Molecules Retains theDecoy Epitope, a Presumed Molecular Cause for Viral Persistence', PLoS ONE10.1371/journal.pone.0065548. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Most of these genes are adjacent to possible novel target proteins for glycosylation.
Benjamin L. Schulz, Freda E. C. Jen, Peter M. Power, Christopher E. Jones, Kate L.Fox, Shan C. Ku, Joanne T. Blanchfield, Michael P. Jennings 2013, 'Identification of Bacterial Protein O-Oligosaccharyltransferases and Their GlycoproteinSubstrates', PLoS ONE10.1371/journal.pone.0062768. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)