a biguanide administered orally in the treatment of diabetes to lower blood concentrations of glucose; it has been largely superseded by metformin. Formula: C10H15N5
Word origin
C20: from phen(yl) + form(aldehyde) +-in
Examples of 'phenformin' in a sentence
phenformin
Among the compounds tested, phenformin and resveratrol had the most pronounced impact on nucleolar organization.
Mohamed Kodiha, Ali Salimi, Yi Meng Wang, Ursula Stochaj 2014, 'Pharmacological AMP kinase activators target the nucleolar organization and controlcell proliferation.', PLoS ONEhttp://europepmc.org/articles/PMC3907577?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This differential effect of biguanides correlated with detection of phenformin, but not metformin, in thymus.
Diana Vara-Ciruelos, Madhumita Dandapani, Fiona M. Russell, Katarzyna M. Grzes, AbdelmadjidAtrih, Marc Foretz, Benoit Viollet, Douglas J. Lamont, Doreen A. Cantrell, D. GrahameHardie 2019, 'Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphomavia Cell-Autonomous AMPK Activation', Cell Reportshttp://www.sciencedirect.com/science/article/pii/S2211124719303973. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These compounds, therefore, represent an improvement over phenformin.
Narise K, Okuda K, Enomoto Y, Hirayama T, Nagasawa H 2014, 'Optimization of biguanide derivatives as selective antitumor agents blocking adaptivestress responses in the tumor microenvironment', Drug Design, Development and Therapyhttp://www.dovepress.com/optimization-of-biguanide-derivatives-as-selective-antitumor-agents-bl-peer-reviewed-article-DDDT. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
While the region-dependent differences were enhanced with phenformin, they were ameliorated by resveratrol.
Mohamed Kodiha, Etienne Flamant, Yi Meng Wang, Ursula Stochaj 2018, 'Defining the short-term effects of pharmacological 5′-AMP activated kinase modulatorson mitochondrial polarization, morphology and heterogeneity', PeerJhttps://peerj.com/articles/5469.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Therefore, this combination of gossypol and phenformin increases irinotecan sensitivity as well as preventing irinotecan resistance.
Soohyun Lee, Jae-Seon Lee, Jinho Seo, Seon-Hyeong Lee, Joon Hee Kang, Jaewhan Song,Soo-Youl Kim 2018, 'Targeting Mitochondrial Oxidative Phosphorylation Abrogated Irinotecan Resistancein NSCLC', Scientific Reportshttp://link.springer.com/article/10.1038/s41598-018-33667-6. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)