There are two ways of individual migration: amoeboid and mesenchymal.
Aleksandra Simiczyjew, Anna Konopnicka, Dorota Nowak 2018, 'Ameboid movement of cancer cells', Postępy Higieny i Medycyny Doświadczalnejhttp://phmd.pl/gicid/01.3001.0010.8134. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Both leukemia cells and leucocytes of healthy donors showed blebs formation (amoeboid motility).
A. Alexandrova, A. Chikina 2015, 'T117', EJC Supplementshttp://www.sciencedirect.com/science/article/pii/S135963491500004X. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, cultivation of all samples showed the presence of amoeboid parasites.
M. L. Gertiser, E. Giagante, E. Sgattoni, N. Basabe, F. Rivero, H. Luján, M. Occhionero,L. Paniccia, E. Visciarelli, S. R. Costamagna 2010, 'Queratitis por Acanthamoeba sp.: primer caso confirmado por aislamiento y tipificaciónmolecular en Bahía Blanca, provincia de Buenos Aires, Argentina Acanthamoeba sp. keratitis:first case confirmed by isolation and molecular typification in Bahía Blanca, BuenosAires Province, Argentina', Revista Argentina de Microbiologíahttp://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-75412010000200011. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Using this set-up we achieved high-speed imaging of amoeboid movements.
Daisuke Takao, Atsushi Taniguchi, Takaaki Takeda, Seiji Sonobe, Shigenori Nonaka 2012, 'High-speed imaging of amoeboid movements using light-sheet microscopy.', PLoS ONEhttp://europepmc.org/articles/PMC3515486?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These characteristics are common in highly motile amoeboid cells that may favour faster motility speeds.
Braet Filip, Condeelis John, Pixley Fiona, Rubin Jeffrey S, Fok Sandra YY, Soon LilianL 2006, 'Rapid chemokinetic movement and the invasive potential of lung cancer cells; a functionalmolecular study', BMC Cancerhttp://www.biomedcentral.com/1471-2407/6/151. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We observe and quantify wave-like characteristics of amoeboid migration.
Meghan K Driscoll, Colin McCann, Rael Kopace, Tess Homan, John T Fourkas, Carole Parent,Wolfgang Losert 2012, 'Cell shape dynamics: from waves to migration.', PLoS Computational Biologyhttp://europepmc.org/articles/PMC3305346?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
During the growth phase, the amoeboid cells proliferate at a definite rate.
Hidekazu Kuwayama, Yukihiro Miyanaga, Hideko Urushihara, Masahiro Ueda 2013, 'A RabGAP regulates life-cycle duration via trimeric G-protein cascades in Dictyosteliumdiscoideum.', PLoS ONEhttp://europepmc.org/articles/PMC3859538?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Amoeboid cells crawl using pseudopods, which are convex extensions of the cell surface.
Peter J. M. Van Haastert 2011, 'Amoeboid Cells Use Protrusions for Walking, Gliding and Swimming', PLoS ONE10.1371/journal.pone.0027532. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We also investigate the effectiveness of amoeboid and mesenchymal motility during migration in differentenvironments.
A. Alexandrova, A. Chikina 2015, 'T117', EJC Supplementshttp://www.sciencedirect.com/science/article/pii/S135963491500004X. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Migrating hematopoietic cells assume a rapid amoeboid like movement when exposed to gradients of chemoattractants.
Silvia Volpe, Sylvia Thelen, Thomas Pertel, Martin J Lohse, Marcus Thelen 2010, 'Polarization of migrating monocytic cells is independent of PI 3-kinase activity.',PLoS ONEhttp://europepmc.org/articles/PMC2855346?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)