a polymer, consisting of polysaccharide and peptide chains, responsible for the structure of the cell wall of bacteria
Also called: murein
Examples of 'peptidoglycan' in a sentence
peptidoglycan
They exert bactericidal action through antimicrobial peptide activity and peptidoglycan hydrolysis.
Ryszard A Zielke, Adriana Le Van, Benjamin I Baarda, Marco F Herrera, ChristopherJ Acosta, Ann E Jerse, Aleksandra E Sikora 2018, 'SliC is a surface-displayed lipoprotein that is required for the anti-lysozyme strategyduring Neisseria gonorrhoeae infection.', PLoS Pathogenshttp://europepmc.org/articles/PMC6033465?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We have identified a new bacterial protein domain that we hypothesise binds to peptidoglycan.
Penny Coggill, Alex Bateman 2012, 'The YARHG domain: an extracellular domain in search of a function.', PLoS ONEhttp://europepmc.org/articles/PMC3355149?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We provide high-resolution evidence of peptidoglycan architecture remodeling at different growth stages.
Kang Li, Xiao-Xue Yuan, He-Min Sun, Long-Sheng Zhao, Ruocong Tang, Zhi-Hua Chen, Qi-LongQin, Xiu-Lan Chen, Yu-Zhong Zhang, Yu-Zhong Zhang, Yu-Zhong Zhang, Hai-Nan Su, Hai-NanSu 2018, 'Atomic Force Microscopy of Side Wall and Septa Peptidoglycan From Bacillus subtilisReveals an Architectural Remodeling During Growth', Frontiers in Microbiologyhttp://journal.frontiersin.org/article/10.3389/fmicb.2018.00620/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Only minor changes of the peptidoglycan and osmoregulated periplasmic glucans were observed.
Susanne Brenzinger, Lizah T. van der Aart, Gilles P. van Wezel, Jean-Marie Lacroix,Timo Glatter, Ariane Briegel 2019, 'Structural and Proteomic Changes in Viable but Non-culturable Vibrio cholerae', Frontiers in Microbiologyhttps://www.frontiersin.org/article/10.3389/fmicb.2019.00793/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The target pathway - peptidoglycan biosynthesis - was upregulated following fosfomycin treatment.
Gruden Kristina, Podlesek Zdravko, Rotter Ana, Kuzman Drago, Baebler Špela, PetekMarko, Ravnikar Maja, Urleb Uroš 2010, 'Revealing fosfomycin primary effect on Staphylococcus aureus transcriptome:modulation of cell envelope biosynthesis and phosphoenolpyruvate induced starvation',BMC Microbiologyhttp://www.biomedcentral.com/1471-2180/10/159. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Recently, a plethora of previously unidentified hydrolases have been suggested to be peptidoglycan degrading amidases.
Juliane Benz, Jochen Reinstein, Anton Meinhart 2013, 'Structural Insights into the Effector - Immunity System Tae4/Tai4 from Salmonellatyphimurium.', PLoS ONEhttp://europepmc.org/articles/PMC3695027?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Another possible link identified for peptidoglycan hydrolases will require further experiments.
Michael Schmid, Michael Schmid, Jonathan Muri, Damianos Melidis, Adithi R. Varadarajan,Adithi R. Varadarajan, Vincent Somerville, Vincent Somerville, Adrian Wicki, AlineMoser, Marc Bourqui, Marc Bourqui, Claudia Wenzel, Elisabeth Eugster-Meier, JuergE. Frey, Stefan Irmler, Christian H. Ahrens, Christian H. Ahrens 2018, 'Comparative Genomics of Completely Sequenced Lactobacillus helveticus Genomes ProvidesInsights into Strain-Specific Genes and Resolves Metagenomics Data Down to the StrainLevel', Frontiers in Microbiologyhttp://journal.frontiersin.org/article/10.3389/fmicb.2018.00063/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Analyses revealed that the physical structure of peptidoglycan was not a principal factor.
Ling Wang, Zhouli Wang, Yahong Yuan, Rui Cai, Chen Niu, Tianli Yue 2015, 'Identification of Key Factors Involved in the Biosorption of Patulin by InactivatedLactic Acid Bacteria (LAB) Cells', PLOS ONE10.1371/journal.pone.0143431. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Antibacterial lysins are enzymes that cleave the peptidoglycan of the bacterial cell wall.
Alexander V. Grishin, Natalia V. Lavrova, Alexander M. Lyashchuk, Natalia V. Strukova,Maria S. Generalova, Anna V. Ryazanova, Nikita V. Shestak, Irina S. Boksha, NikitaB. Polyakov, Zoya M. Galushkina, Lyubov A. Soboleva, Sergey S. Vetchinin, VitaliyM. Pavlov, Anna S. Karyagina, Vladimir G. Lunin 2019, 'The Influence of Dimerization on the Pharmacokinetics and Activity of an AntibacterialEnzyme Lysostaphin', Moleculeshttps://www.mdpi.com/1420-3049/24/10/1879. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Nearly all bacteria contain a peptidoglycan cell wall.
Dirk-Jan Scheffers, Menno B Tol 2015, 'LipidII: Just Another Brick in the Wall?', PLoS Pathogenshttp://europepmc.org/articles/PMC4683061?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)