In vivo, the pentacyclic nitrofuran compounds showed long half-lives and high volumes of distribution.
Rakesh, David F Bruhn, Michael S Scherman, Lisa K Woolhiser, Dora B Madhura, MarcusM Maddox, Aman P Singh, Robin B Lee, Julian G Hurdle, Michael R McNeil, Anne J Lenaerts,Bernd Meibohm, Richard E Lee 2014, 'Pentacyclic nitrofurans with in vivo efficacy and activity against nonreplicatingMycobacterium tuberculosis.', PLoS ONEhttp://europepmc.org/articles/PMC3914891?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Pentacyclic triterpenoid, a biologically diverse plant-derived natural product, has been reported to show anti-staphylococcal activities.
Navaratnam Parasakthi, Chung Pooi, Chung Lip 2011, 'Synergistic antimicrobial activity between pentacyclic triterpenoids and antibioticsagainst Staphylococcus aureus strains', Annals of Clinical Microbiology and Antimicrobialshttp://www.ann-clinmicrob.com/content/10/1/25. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The phytochemical analysis resulted in the isolation of pentacyclic triterpenes, flavonoids, and phenol acids.
Joelma Abadia Marciano de Paula, Maria do Rosário Rodrigues Silva, Maysa P. Costa,Danielle Guimarães Almeida Diniz, Fabyola A. S. Sá, Suzana Ferreira Alves, Élson AlvesCosta, Roberta Campos Lino, José Realino de Paula 2012, 'Phytochemical Analysis and Antimicrobial, Antinociceptive, and Anti-InflammatoryActivities of Two Chemotypes of Pimenta pseudocaryophyllus (Myrtaceae)', Evidence-Based Complementary and Alternative Medicinehttp://dx.doi.org/10.1155/2012/420715. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark.
Armin Scheffler, Melanie N. Laszczyk, Holger Trojan, Thomas Kopp, Sebastian Jäger 2009, 'Pentacyclic Triterpene Distribution in Various Plants – Rich Sources for a New Groupof Multi-Potent Plant Extracts', Moleculeshttp://www.mdpi.com/1420-3049/14/6/2016/. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In this review, we will explore the chemodiversity of tri- and pentacyclic guanidine alkaloids.
Estelle Sfecci, Thierry Lacour, Philippe Amade, Mohamed Mehiri 2016, 'Polycyclic Guanidine Alkaloids from Poecilosclerida Marine Sponges', Marine Drugshttp://www.mdpi.com/1660-3397/14/4/77. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Centella asiatica accumulates large quantities of pentacyclic triterpenoid saponins, collectively known as centelloids.
Dewi Sondari, Sri Budi Harmami, M. Ghozali, Ahmad Randy, Athanasia Amanda S., YanIrawan 2011, 'Determination of The Active Asiaticoside Content in Centella asiatica as Anti-CelluliteAgent', ISCC (Indonesian Journal of Cancer Chemoprevention)https://ijcc.chemoprev.org/index.php/ijcc/article/view/35. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This article reviews the microbial modifications of tetranortriterpenoids, tetracyclic triterpenoids and pentacyclic triterpenoids.
Syed Adnan Ali Shah, Huey Ling Tan, Sadia Sultan, Muhammad Afifi Bin Mohd Faridz,Mohamad Azlan Bin Mohd Shah, Sharifah Nurfazilah, Munawar Hussain 2014, 'Microbial-Catalyzed Biotransformation of Multifunctional Triterpenoids Derived fromPhytonutrients', International Journal of Molecular Scienceshttp://www.mdpi.com/1422-0067/15/7/12027. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Hopanoids are pentacyclic triterpenoid lipids synthesized by different bacterial groups.
Jaap S. Sinninghe Damsté, Jaap S. Sinninghe Damsté, W. Irene C. Rijpstra, SvetlanaN. Dedysh, Bärbel U. Foesel, Laura Villanueva 2017, 'Pheno- and Genotyping of Hopanoid Production in Acidobacteria', Frontiers in Microbiologyhttp://journal.frontiersin.org/article/10.3389/fmicb.2017.00968/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Two new aglycones were also isolated and identified as pentacyclic triterpens of β-amyrin structure.
Piotr M. Górski, Marian Jurzysta, Stanisław Burda, Wiesław A. Oleszek, Michał Płoszyński 2014, 'Studies on Medicago lupulina saponins. 1. Isolation and identification of sapogeninsfrom M. lupulina tops', Acta Societatis Botanicorum Poloniaehttps://pbsociety.org.pl/journals/index.php/asbp/article/view/3137. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Betulin, betulinic acid and lupeol are naturally occurring pentacyclic triterpenoids with significant medicinal values.
Shenglei Guo, Dehui Zhang, Huanyong Wei, Yinan Zhao, Yibo Cao, Tao Yu, Yang Wang,Xiufeng Yan 2017, 'Climatic Factors Shape the Spatial Distribution of Concentrations of Triterpenoidsin Barks of White Birch (Betula Platyphylla Suk.) Trees in Northeast China', Forestshttps://www.mdpi.com/1999-4907/8/9/334. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)