an enzyme acting as a catalyst in the hydrolysis of an amide
amidase in American English
(ˈæmɪˌdeis, -ˌdeiz)
noun
Biochemistry
an enzyme that catalyzes the hydrolysis of an acid amide
Word origin
[1920–25; amid- + -ase]This word is first recorded in the period 1920–25. Other words that entered Englishat around the same time include: fundamentalism, montage, self-service, slalom, tie-in-ase is a suffix used in the names of enzymes. Other words that use the affix -ase include: hyaluronidase, oxidase, phosphorylase, reverse transcriptase, zymase
Examples of 'amidase' in a sentence
amidase
However, actin did not impede plasmin autolysis and had no influence on its amidase activity.
Yusova E. I. 2015, 'Plasmin enzymatic activity in the presence of actin', Biopolymers and Cellhttp://biopolymers.org.ua/pdf/31/5/345/. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
It contains two major domains: the amidase and urea carboxylase domains.
Harris Steven D, Nickerson Kenneth W, Strope Pooja K, Moriyama Etsuko N 2011, 'Molecular evolution of urea amidolyase and urea carboxylase in fungi', BMC Evolutionary Biologyhttp://www.biomedcentral.com/1471-2148/11/80. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, the amidase-lacking endolysins had reduced hydrolytic activity compared to the full-length endolysins.
Bokyung Son, Minsuk Kong, Sangryeol Ryu 2018, 'The Auxiliary Role of the Amidase Domain in Cell Wall Binding and Exolytic Activityof Staphylococcal Phage Endolysins', Viruseshttp://www.mdpi.com/1999-4915/10/6/284. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Mass spectrometric analysis also indicated the presence of partial sequences of antimicrobial enzymes, amidase and dd-carboxypeptidase.
Rawana N. Alkhalili, Katja Bernfur, Tarek Dishisha, Gashaw Mamo, Jenny Schelin, BjörnCanbäck, Cecilia Emanuelsson, Rajni Hatti-Kaul 2016, 'Antimicrobial Protein Candidates from the Thermophilic Geobacillus sp. Strain ZGt-1:Production, Proteomics, and Bioinformatics Analysis', International Journal of Molecular Scienceshttp://www.mdpi.com/1422-0067/17/8/1363. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Despite extensive studies using truncated staphylococcal endolysins, the precise function of the amidase domain has not been determined.
Bokyung Son, Minsuk Kong, Sangryeol Ryu 2018, 'The Auxiliary Role of the Amidase Domain in Cell Wall Binding and Exolytic Activityof Staphylococcal Phage Endolysins', Viruseshttp://www.mdpi.com/1999-4915/10/6/284. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Here, we show that the amidase domain can be used as an in vivo probe which specifically inactivates lipoylated enzymes.
Maroya D Spalding, Sean T Prigge 2009, 'The amidase domain of lipoamidase specifically inactivates lipoylated proteins invivo.', PLoS ONEhttp://europepmc.org/articles/PMC2753649?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)