Phylogenetic analyses of nucleotide and deduced amino acid sequences demonstrated dual paralogy between teleost and human aquaporins.
Chauvigné François, Finn Roderick N, Calusinska Magdalena, Tingaud-Sequeira Angèle,Lozano Juanjo, Cerdà Joan 2010, 'The zebrafish genome encodes the largest vertebrate repertoire of functional aquaporinswith dual paralogy and substrate specificities similar to mammals', BMC Evolutionary Biologyhttp://www.biomedcentral.com/1471-2148/10/38. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These events obscure the paralogy relationships but are still tractable thanks to the many genomes now available.
Ocampo Daza Daniel, Sundström Görel, Bergqvist Christina A, Larhammar Dan 2012, 'The evolution of vertebrate somatostatin receptors and their gene regions involvesextensive chromosomal rearrangements', BMC Evolutionary Biologyhttp://www.biomedcentral.com/1471-2148/12/231. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Accurate predictions of orthology and paralogy relationships are necessary to infer human molecular function from experiments in model organisms.
Leo Goodstadt, Chris P Ponting 2006, 'Phylogenetic reconstruction of orthology, paralogy, and conserved synteny for dogand human.', PLoS Computational Biologyhttp://europepmc.org/articles/PMC1584324?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)