relating to a hormone whose release only affects tissue surrounding the gland that secreted it
Examples of 'paracrine' in a sentence
paracrine
Chemokines are crucial autocrine and paracrine players in tumor development.
Roberto eWurth, Adriana eBajetto, Jeffrey K. Harrison, Federica eBarbieri, TullioeFlorio 2014, 'CXCL12 MODULATION OF CXCR4 AND CXCR7 ACTIVITY IN HUMAN GLIOBLASTOMA STEM-LIKE CELLSAND REGULATION OF THE TUMOR MICROENVIRONMENT', Frontiers in Cellular Neurosciencehttp://journal.frontiersin.org/Journal/10.3389/fncel.2014.00144/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The membrane permeability of such molecules has potential importance for autocrine like or paracrine-like delivery.
Virginijus eValiunas 2013, 'Cyclic nucleotide permeability through unopposed connexin hemichannels', Frontiers in Pharmacologyhttp://journal.frontiersin.org/Journal/10.3389/fphar.2013.00075/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Another way of intercellular interaction involves mutual influence via paracrine factors produced by corresponding cells.
Shkarina K. A., Cherednyk O. V., Voloschenko I. I., Trembach O. M., Trembach I. O.,Khoruzhenko A. I. 2014, 'Exosomes: messengers and mediators of tumor–stromal interactions', Biopolymers and Cellhttp://biopolymers.org.ua/pdf/30/6/426/. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
It has been shown that the biological effect depends mainly on its paracrine action.
Consuelo eMerino, Felipe A Zuñiga, Carlos Alonso Escudero, Carlos Alonso Escudero,Carlos Alonso Escudero, Valeska eOrmazabanl, Camila eReyes, Carlos eSalomon, ClaudioeAguayo, Claudio eAguayo, Claudio eAguayo 2016, 'Mesenchymal stem cell-derived extracellular vesicles promote angiogenesis: New alternativesfor application to human health.', Frontiers in Physiologyhttp://journal.frontiersin.org/Journal/10.3389/fphys.2016.00024/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Exosomes are emerging as an attractive vector of paracrine signals delivered by progenitor cells.
Lucio Barile, Mihaela Gherghiceanu, Laurentiu M. Popescu, Tiziano Moccetti, GiuseppeVassalli 2012, 'Ultrastructural Evidence of Exosome Secretion by Progenitor Cells in Adult Mouse Myocardiumand Adult Human Cardiospheres', Journal of Biomedicine and Biotechnologyhttp://dx.doi.org/10.1155/2012/354605. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, their direct effect on endothelial cells and paracrine mediators have notyet been investigated.
Leonie Rosenberger, Marcelo Ezquer, Fernando Lillo-Vera, Paulina L. Pedraza, MaríaIgnacia Ortúzar, Paz L. González, Aliosha I. Figueroa-Valdés, Jimena Cuenca, FernandoEzquer, Maroun Khoury, Francisca Alcayaga-Miranda 2019, 'Stem cell exosomes inhibit angiogenesis and tumor growth of oral squamous cell carcinoma',Scientific Reportshttp://link.springer.com/article/10.1038/s41598-018-36855-6. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The data can be useful for clarifying the paracrine effects exerted by the injected cells.
Giorgio Vescovo, Chiara Castellani, Marny Fedrigo, Grazia Maria Virzì, Giovanni MariaVescovo, Regina Tavano, Michela Pozzobon, Annalisa Angelini 2018, 'Data on the stem cells paracrine effects on apoptosis and cytokine milieu in an experimentalmodel of cardiorenal syndrome type II', Data in Briefhttp://www.sciencedirect.com/science/article/pii/S2352340918313441. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This study provides evidence that exosomes function as paracrine mediators of labor and delivery.
Samantha Sheller-Miller, Jayshil Trivedi, Steven M. Yellon, Ramkumar Menon 2019, 'Exosomes Cause Preterm Birth in Mice: Evidence for Paracrine Signaling in Pregnancy',Scientific Reportshttp://link.springer.com/article/10.1038/s41598-018-37002-x. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Extracellular vesicles are considered to be some of the most valuable paracrine molecules.
Yanhui Lu, Yanhui Lu, Yan Zhou, Ruiyi Zhang, Ruiyi Zhang, Lulu Wen, Kaimin Wu, YanfeiLi, Yaobing Yao, Ranran Duan, Yanjie Jia 2019, 'Bone Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Recovery FollowingSpinal Cord Injury via Improvement of the Integrity of the Blood-Spinal Cord Barrier',Frontiers in Neurosciencehttps://www.frontiersin.org/article/10.3389/fnins.2019.00209/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)