a reddish organic compound C4H2N2O4 produced by oxidation of uric acid
alloxan in American English
(əˈlɑksən)
noun
Biochemistry
a white crystalline pyrimidine derivative, C4H2O4N2, used in biomedical research to induce diabetes in laboratory animals
Word origin
[‹ G, equiv. to All(antoïn) allantoin + Ox(alsäure) oxalicacid + -an-an; coined by J. von liebig in 1838]
Examples of 'alloxan' in a sentence
alloxan
Liver function test also showed significant changes (p<0.001) as compared to alloxan-treated group.
Muhammad Saad Ur Rehman, Sairah Hafeez Kamran, Mobasher Ahmad, Usman Akhtar 2015, 'Anti-diabetic activity of crude Pistacia lentiscus in alloxan-induced diabetes inrats', Bangladesh Journal of Pharmacologyhttp://www.banglajol.info/index.php/BJP/article/view/23225. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
At 200 mg/kg, the extracts reversed cardiac and liver damage caused by alloxan.
Sumaiya Nahid, Kishor Mazumder, Zillur Rahman, Saiful Islam, Md. Humayun Rashid, PhilipGrey Kerr 2017, 'Cardio- and hepato-protective potential of methanolic extract of Syzygium cumini (L.)Skeels seeds: A diabetic rat model study', Asian Pacific Journal of Tropical Biomedicinehttp://www.sciencedirect.com/science/article/pii/S2221169116305147. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Second and third groups were diabetic with injection of alloxan(120 mg/kg).
hasan ahmadvand, majid tavafi, gholamreza shahsavari, ali Khosrowbeygi, foad Abdolahpour,shahrokh bagheri, leila nemati 2011, 'The effects of Coenzyme Q10 on serum lipid profile in male rats diabetic', Yaftehhttp://yafte.lums.ac.ir/browse.php?a_code=A-10-145-185&slc_lang=en&sid=1. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Alloxan caused the fasting blood sugar level to increase.
Raja Serairi Beji, Sameh Khemir, Wissem Aidi Wannes, Khaoula Ayari, Riadh Ksouri 2018, 'Antidiabetic, antihyperlipidemic and antioxidant influences of the spice cinnamon( Cinnamomum zeylanicumon ) in experimental rats', Brazilian Journal of Pharmaceutical Scienceshttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200604&lng=en&tlng=en. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Partial dysfunction of the pancreas was induced with alloxan.
Rozman J., Bunc M., Zorko B. 2004, 'Modulation of hormone secretion by functional electrical stimulation of the intactand incompletely dysfunctional dog pancreas', Brazilian Journal of Medical and Biological Researchhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000300012. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Doses of 120, 150, 200mg/kg alloxan 2% and control group were compared.
Valter Dias da Silva , Rosa Maria Barilli Nogueira , Gloriane Izabel Vojciechoviskde Oliveira , Rogério Giuffrida 2014, 'Comparison of induction of Diabetes mellitus with alloxan in different doses in Wistarrats', Semina: Ciências Agráriashttp://www.uel.br/revistas/uel/index.php/semagrarias/editor/submission/15706. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This observation necessitated the review of alloxan as a diabetogenic agent in animal studies.
Osasenaga Macdonald Ighodaro, Abiola Mohammed Adeosun, Oluseyi Adeboye Akinloye 2017, 'Alloxan-induced diabetes, a common model for evaluating the glycemic-control potentialof therapeutic compounds and plants extracts in experimental studies', Medicinahttp://www.sciencedirect.com/science/article/pii/S1010660X18300107. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Alloxan-induced pancreatic beta cell damage was examined by immunohistochemical staining of insulin.
Jill K. Badin, Ayeeshik Kole, Benjamin Stivers, Victor Progar, Anisha Pareddy, MouhamadAlloosh, Michael Sturek 2018, 'Alloxan-induced diabetes exacerbates coronary atherosclerosis and calcification inOssabaw miniature swine with metabolic syndrome', Journal of Translational Medicinehttp://link.springer.com/article/10.1186/s12967-018-1431-9. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)