any of a class of enzymes that control the coiling of DNA molecules
Examples of 'topoisomerase' in a sentence
topoisomerase
Properties of these topoisomerase-like waves are different from electromagnetic and gravitational waves.
Sepehri Alireza, Fioranelli Massimo 2018, '4 + n-dimensional water and waves on four and eleven-dimensional manifolds', Open Physicshttp://www.degruyter.com/view/j/phys.2018.16.issue-1/phys-2018-0063/phys-2018-0063.xml?format=INT. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Topoisomerase inhibitors are agents with anticancer activity.
N.F. Grynberg, M.G. Carvalho, J.R. Velandia, M.C. Oliveira, I.C. Moreira, R. Braz-Filho, A. Echevarria 2002, 'DNA topoisomerase inhibitors: biflavonoids from Ouratea species', Brazilian Journal of Medical and Biological Researchhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000700009. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Akt inhibitor-induced enhancement of topoisomerase inhibitor cytotoxicity was also evident in long-term cell survival assay.
Yan Shi, Xuesong Liu, Edward K. Han, Ran Guan, Alexander R. Shoemaker, Anatol Oleksijew,Keith W. Woods, John P. Fisher, Vered Klinghofer, Loren Lasko, Thomas McGonigal, QunLi, Saul H. Rosenberg, Vincent L. Giranda, Yan Luo 2005, 'Optimal Classes of Chemotherapeutic Agents Sensitized by Specific Small-Molecule Inhibitorsof Akt In Vitro and In Vivo', Neoplasia: An International Journal for Oncology Researchhttp://www.sciencedirect.com/science/article/pii/S147655860580034X. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In this study we validate a novel assay for screening topoisomerase inhibitors.
James A. Taylor, Lesley A. Mitchenall, Martin Rejzek, Robert A. Field, Anthony Maxwell 2013, 'Application of a Novel Microtitre Plate-Based Assay for the Discovery of New Inhibitorsof DNA Gyrase and DNA Topoisomerase VI', PLoS ONE10.1371/journal.pone.0058010. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Se-compounds showed synergistic interactions with chemotherapeutic agents targeting the topoisomerase enzymes or the microtubule apparatus.
Gabriella Spengler, Márió Gajdács, Małgorzata Anna Marć, Enrique Domínguez-Álvarez,Carmen Sanmartín 2019, 'Organoselenium Compounds as Novel Adjuvants of Chemotherapy Drugs—A Promising Approachto Fight Cancer Drug Resistance', Moleculeshttp://www.mdpi.com/1420-3049/24/2/336. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Topoisomerase inhibitors have been developed in a variety of clinical applications.
Jau-Lang Hwang, Chiao-En Chen, Chun-Mao Lin, Chi-Ming Lee, Agnes L.-F. Chan, Wen-ShinChang, Li-Min Chen 2009, 'Evodiamine Stabilizes Topoisomerase I-DNA Cleavable Complex to Inhibit TopoisomeraseI Activity', Moleculeshttp://www.mdpi.com/1420-3049/14/4/1342/. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The main risk factors for incident cardiac manifestations were anti-topoisomerase autoantibody positivity and older age.
Veronika K Jaeger, Elina G Wirz, Yannick Allanore, Philipp Rossbach, Gabriela Riemekasten,Eric Hachulla, Oliver Distler, Paolo Airò, Patricia E Carreira, Alexandra Balbir Gurman,Mohammed Tikly, Serena Vettori, Nemanja Damjanov, Ulf Müller-Ladner, Jörg H W Distler,Mangtao Li, Ulrich A Walker 2016, 'Incidences and Risk Factors of Organ Manifestations in the Early Course of SystemicSclerosis: A Longitudinal EUSTAR Study.', PLoS ONEhttp://europepmc.org/articles/PMC5051961?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Topoisomerase activity was present in both species.
PAOLUCCI M., DI CRISTO C., LIBERATO C., DI COSMO A. 2004, 'FIRST RESULTS ABOUT TOPOISOMERASE ACTIVITY IN ASTACUS ASTACUS AND AUSTROPOTAMOBIUSPALLIPES AS A BIOMARKER FOR CRAYFISH VIABILITY', Knowledge and Management of Aquatic Ecosystemshttp://dx.doi.org/10.1051/kmae:2004013. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
None of the isolates susceptible to ciprofloxacin presented mutations in topoisomerase genes.
Luciene A. R. Minarini, Ana Lucia C. Darini 2012, 'Mutations in the quinolone resistance-determining regions of gyrA and parC in Enterobacteriaceaeisolates from Brazil', Brazilian Journal of Microbiologyhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822012000400010. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Naphthoquinones have been extensively studied due to their activity as topoisomerase inhibitors.
Silva Milton N. da, Ferreira Vítor F., Souza Maria Cecília B. V. de 2003, 'Um panorama atual da química e da farmacologia de naftoquinonas, com ênfase na b-lapachonae derivados', Química Novahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422003000300019. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)