any cell which develops into bone or secretes substances producing bony tissue
Derived forms
osteoblastic (ˌosteoˈblastic)
adjective
Word origin
osteo- + -blast
osteoblast in American English
(ˈɑstiəˌblæst)
noun
Anatomy
a bone-forming cell
Derived forms
osteoblastic
adjective
Word origin
[1870–75; osteo- + -blast]This word is first recorded in the period 1870–75. Other words that entered Englishat around the same time include: Mafia, fifth wheel, giveaway, linkage, washoutosteo- is a combining form meaning “bone,” used in the formation of compound words. Otherwords that use the affix osteo- include: osteoclast, osteogenic, osteoplasty, osteoporosis, osteotomy; -blast is a suffix meaning “bud, sprout,” “embryo,” “formative cells or cell layer”. Otherwords that use the affix -blast include: mesoblast, myoblast, odontoblast, spongioblast, statoblast
Examples of 'osteoblast' in a sentence
osteoblast
Mitochondrial abnormalities are closely related to osteoblast dysfunction.
Y. X. Mao, W. J. Cai, X. Y. Sun, P. P. Dai, X. M. Li, Q. Wang, X. L. Huang, B. He,P. P. Wang, G. Wu, J. F. Ma, S. B. Huang 2018, 'RAGE-dependent mitochondria pathway: a novel target of silibinin against apoptosisof osteoblastic cells induced by advanced glycation end products', Cell Death and Diseasehttp://link.springer.com/article/10.1038/s41419-018-0718-3. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
First, the osteoclast and osteoblast activities were coupled by their autocrine and paracrine effects.
Lingze Liu, Quan Shi, Qiang Chen, Zhiyong Li 2019, 'Mathematical modeling of bone in-growth into undegradable porous periodic scaffoldsunder mechanical stimulus', Journal of Tissue Engineeringhttps://doi.org/10.1177/2041731419827167. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Osteocytes are terminally differentiated cells of the osteoblast lineage.
Denise Toscani, Marina Bolzoni, Marzia Ferretti, Carla Palumbo, Nicola Giuliani 2018, 'Role of Osteocytes in Myeloma Bone Disease: Anti-sclerostin Antibody as New TherapeuticStrategy', Frontiers in Immunologyhttps://www.frontiersin.org/article/10.3389/fimmu.2018.02467/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Recent in vitro studies support a role of osteoblast impairment in iron-related osteoporosis.
Mathilde Doyard, Daniel Chappard, Patricia Leroyer, Marie-Paule Roth, Olivier Loréal,Pascal Guggenbuhl 2016, 'Decreased Bone Formation Explains Osteoporosis in a Genetic Mouse Model of Hemochromatosiss.',PLoS ONEhttp://europepmc.org/articles/PMC4734777?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Preosteoblasts are precursor cells that are committed to the osteoblast lineage.
Jianquan Chen, Fanxin Long 2015, 'mTORC1 Signaling Promotes Osteoblast Differentiation from Preosteoblasts', PLOS ONE10.1371/journal.pone.0130627. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, the molecular mechanisms involved in osteoblast function remain incompletely understood.
Zhong-Jian Shen, Jie Hu, Aktar Ali, Johanne Pastor, Kazuhiro Shiizaki, Robert D. Blank,Makoto Kuro-o, James S. Malter 2013, 'Pin1 Null Mice Exhibit Low Bone Mass and Attenuation of BMP Signaling', PLoS ONE10.1371/journal.pone.0063565. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In this study, osteoblast growth under hypoxia was examined.
Dafu Chen, Yang Li, Zhiyu Zhou, Yonggang Xing, Yu Zhong, Xuenong Zou, Wei Tian, ChiZhang 2012, 'Synergistic Inhibition of Wnt Pathway by HIF-1α and Osteoblast-Specific TranscriptionFactor Osterix (Osx) in Osteoblasts', PLoS ONE10.1371/journal.pone.0052948. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Our results also highlighted a number of novel osteoblast-relevant genes.
Fangtang Yu, Hui Shen, Hong-Wen Deng 2017, 'Systemic analysis of osteoblast-specific DNA methylation marks reveals novel epigeneticbasis of osteoblast differentiation', Bone Reportshttp://www.sciencedirect.com/science/article/pii/S235218721730013X. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)