the quality of being essential; essential character
2.
an essential feature, element, or point
Word origin
[1610–20; essential + -ity]This word is first recorded in the period 1610–20. Other words that entered Englishat around the same time include: institutional, integration, squelch, tank, telescope-ity is a suffix used to form abstract nouns expressing state or condition. Other wordsthat use the affix -ity include: Latinity, civility, jollity
Examples of 'essentiality' in a sentence
essentiality
Gene essentiality was assessed by competitive growth assays and chemogenomic profiling.
Aiyada Aroonsri, Navaporn Posayapisit, Jindaporn Kongsee, Onsiri Siripan, Danoo Vitsupakorn,Sugunya Utaida, Chairat Uthaipibull, Sumalee Kamchonwongpaisan, Philip J. Shaw 2019, 'Validation of Plasmodium falciparum deoxyhypusine synthase as an antimalarial target',PeerJhttps://peerj.com/articles/6713.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Gene essentiality and hydrogen production potential have also been assessed.
Urchueguía Javier F, Fernández de Córdoba Pedro, Navarro Emilio, Montagud Arnau, PatilKiran 2010, 'Reconstruction and analysis of genome-scale metabolic model of a photosynthetic bacterium',BMC Systems Biologyhttp://www.biomedcentral.com/1752-0509/4/156. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Essentiality study was conducted to predict essential genes on different growth media.
Liu Ting, Zou Wei, Liu Liming, Chen Jian 2012, 'A constraint-based model of Scheffersomyces stipitis for improved ethanolproduction', Biotechnology for Biofuelshttp://www.biotechnologyforbiofuels.com/content/5/1/72. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Their essentiality for reproduction should also be explored.
Vance L. Trudeau 2018, 'Facing the Challenges of Neuropeptide Gene Knockouts: Why Do They Not Inhibit Reproductionin Adult Teleost Fish?', Frontiers in Neurosciencehttp://journal.frontiersin.org/article/10.3389/fnins.2018.00302/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Various computational models have been developed to transfer annotations of gene essentiality between organisms.
Jian Cheng, Zhao Xu, Wenwu Wu, Li Zhao, Xiangchen Li, Yanlin Liu, Shiheng Tao 2014, 'Training set selection for the prediction of essential genes.', PLoS ONEhttp://europepmc.org/articles/PMC3899339?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Established cancer dependencies and essentiality signals of amplified cancer driver genes are detectable post-correction.
Francesco Iorio, Fiona M. Behan, Emanuel Gonçalves, Shriram G. Bhosle, Elisabeth Chen,Rebecca Shepherd, Charlotte Beaver, Rizwan Ansari, Rachel Pooley, Piers Wilkinson,Sarah Harper, Adam P. Butler, Euan A. Stronach, Julio Saez-Rodriguez, Kosuke Yusa,Mathew J. Garnett 2018, 'Unsupervised correction of gene-independent cell responses to CRISPR-Cas9 targeting',BMC Genomicshttp://link.springer.com/article/10.1186/s12864-018-4989-y. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Gene essentiality can also be predicted but accurate predictions remain difficult to obtain.
Rienk A. Rienksma, Peter J. Schaap, Vitor A. P. Martins dos Santos, Maria Suarez-Diez 2018, 'Modeling the Metabolic State of Mycobacterium tuberculosis Upon Infection', Frontiers in Cellular and Infection Microbiologyhttps://www.frontiersin.org/article/10.3389/fcimb.2018.00264/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Among those are their essentiality, druggability, availability of structural information, and selectivity.
Juan Felipe Osorio-Méndez, Juan Felipe Osorio-Méndez, Ana María Cevallos 2019, 'Discovery and Genetic Validation of Chemotherapeutic Targets for Chagas' Disease',Frontiers in Cellular and Infection Microbiologyhttps://www.frontiersin.org/article/10.3389/fcimb.2018.00439/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, current methods do not permit efficiently and accurately quantifying reaction/gene essentiality.
Cheng Zhang, Gholamreza Bidkhori, Rui Benfeitas, Sunjae Lee, Muhammad Arif, MathiasUhlén, Adil Mardinoglu, Adil Mardinoglu, Adil Mardinoglu 2018, 'ESS: A Tool for Genome-Scale Quantification of Essentiality Score for Reaction/Genesin Constraint-Based Modeling', Frontiers in Physiologyhttps://www.frontiersin.org/article/10.3389/fphys.2018.01355/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Absence of paralogues was also found to be a general predictor of increased relative essentiality.
Hall Ross S, Woodcroft Ben J, Gasser Robin B, Doyle Maria A, Ralph Stuart A 2010, 'Drug target prediction and prioritization: using orthology to predict essentialityin parasite genomes', BMC Genomicshttp://www.biomedcentral.com/1471-2164/11/222. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)