any of a group of compounds, including the leukotrienes and the prostglandins, which are produced by the oxygenation of essential fatty acids and which are involved in a range of physiological processes, including inflammation and immunity
Examples of 'eicosanoid' in a sentence
eicosanoid
This was only partly provided by eicosanoid serum concentrations.
Jörn Lötsch, Michael Thrun, Florian Lerch, Robert Brunkhorst, Susanne Schiffmann,Dominique Thomas, Irmgard Tegder, Gerd Geisslinger, Alfred Ultsch 2017, 'Machine-Learned Data Structures of Lipid Marker Serum Concentrations in Multiple SclerosisPatients Differ from Those in Healthy Subjects', International Journal of Molecular Scienceshttp://www.mdpi.com/1422-0067/18/6/1217. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Both inhibitors induced a rapid increase in eicosanoid production.
Florence Borot, Diane-Lore Vieu, Grazyna Faure, Janine Fritsch, Julien Colas, SandraMoriceau, Maryvonne Baudouin-Legros, Franck Brouillard, Jesus Ayala-Sanmartin, LhousseineTouqui, Marc Chanson, Aleksander Edelman, Mario Ollero 2009, 'Eicosanoid release is increased by membrane destabilization and CFTR inhibition inCalu-3 cells.', PLoS ONEhttp://europepmc.org/articles/PMC2760709?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, the detailed regulation of eicosanoid production and its involvement in macrophage biology remains unclear.
Carlos A. Sorgi, Simona Zarini, Sarah A. Martin, Raphael L. Sanchez, Rodrigo F. Scandiuzzi,Miguel A. Gijón, Carlos Guijas, Nicolas Flamand, Robert C. Murphy, Lucia H. Faccioli 2017, 'Dormant 5-lipoxygenase in inflammatory macrophages is triggered by exogenous arachidonicacid', Scientific Reportshttp://link.springer.com/article/10.1038/s41598-017-11496-3. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Analysis revealed that early ischemia induces both pro-inflammatory and anti-inflammatory eicosanoid production.
Thomas Gobbetti, Pauline Le Faouder, Justine Bertrand, Marc Dubourdeau, ElisabettaBarocelli, Nicolas Cenac, Nathalie Vergnolle 2013, 'Polyunsaturated fatty acid metabolism signature in ischemia differs from reperfusionin mouse intestine.', PLoS ONEhttp://europepmc.org/articles/PMC3779198?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Cytokine and eicosanoid concentrations were not significantly changed.
Cynthia do Prado Vendruscolo, Juliana Junqueira Moreira, Sarah Raphaela Torquato Seidel,Joice Fülber, Henrique Macedo Neuenschwander, Giancarlo Bonagura, Fernanda RodriguesAgreste, Raquel Yvonne Arantes Baccarin 2018, 'Effects of medical ozone upon healthy equine joints: Clinical and laboratorial aspects.',PLoS ONEhttp://europepmc.org/articles/PMC5973567?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Serum and urinary eicosanoid metabolites, sphingosine-1-phosphate, were evaluated by quadrupole time-of-flight mass spectrometry.
Sailesh Palikhe, Udval Uuganbayar, Hoang Kim Tu Trinh, Ga-Young Ban, Eun-Mi Yang,Hae-Sim Park, Seung-Hyun Kim 2017, 'A Role of the ABCC4 Gene Polymorphism in Airway Inflammation of Asthmatics', Mediators of Inflammationhttp://dx.doi.org/10.1155/2017/3549375. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Common products are 7,8-dihydroxyeicosatetraenoic acid and a novel eicosanoid withan unusual γ-lactone moiety.
Martin Rempt, Florian Weinberger, Katharina Grosser, Georg Pohnert 2012, 'Conserved and species-specific oxylipin pathways in the wound-activated chemical defenseof the noninvasive red alga Gracilaria chilensis and the invasive Gracilaria vermiculophylla',Beilstein Journal of Organic Chemistryhttps://doi.org/10.3762/bjoc.8.30. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This increase was still observed when neutrophils were treated with inhibitors of eicosanoid synthesis.
Rachel Vaivoda, Christine Vaine, Cassandra Boerstler, Kristy Galloway, Peter Christmas 2015, 'CYP4F18-Deficient Neutrophils Exhibit Increased Chemotaxis to Complement ComponentC5a', Journal of Immunology Researchhttp://dx.doi.org/10.1155/2015/250456. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
They also exhibit profound effects on eicosanoid production.
Shahida A. Khan, Ashraf Ali, Sarah A. Khan, Solafa A. Zahran, Ghazi Damanhouri, EsamAzhar, Ishtiaq Qadri 2014, 'Unraveling the Complex Relationship Triad between Lipids, Obesity, and Inflammation',Mediators of Inflammationhttp://dx.doi.org/10.1155/2014/502749. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These results were confirmed by eicosanoid measurements through enzyme-linked immunoassays.
Julio J Amaral, Luis Caetano M Antunes, Cristiana S de Macedo, Katherine A Mattos,Jun Han, Jingxi Pan, André L P Candéa, Maria das Graças M O Henriques, Marcelo Ribeiro-Alves,Christoph H Borchers, Euzenir N Sarno, Patrícia T Bozza, B Brett Finlay, Maria CristinaV Pessolani 2013, 'Metabonomics reveals drastic changes in anti-inflammatory/pro-resolving polyunsaturatedfatty acids-derived lipid mediators in leprosy disease.', PLoS Neglected Tropical Diseaseshttp://europepmc.org/articles/PMC3744420?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)