having or involving an affinity for positive charge. Nucleophilic reagents (nucleophiles) are molecules, atoms, and ions that behave as electron donors
Compare electrophilic
nucleophilic in American English
(ˌnuːkliəˈfɪlɪk, ˌnjuː-)
adjective
Chemistry
of or pertaining to electron contribution in covalent bonding (opposed to electrophilic)
Derived forms
nucleophile (ˈnuːkliəˌfail, ˈnjuː-)
noun
Word origin
[1930–35; nucleo- + -philic]
Examples of 'nucleophilic' in a sentence
nucleophilic
Results are now being presented for mechanical pulp brightening, where nucleophilic reactions were observed.
Francis K Attiogbe, Wei Wang, Alastair McNeillie, Ray C. Francis 2010, 'THE PEROXYMONOCARBONATE ANIONS AS PULP BLEACHING AGENTS. Part 2. MECHANICAL PULP BRIGHTENINGAND EFFECTS OF METAL IONS', BioResourceshttp://ojs.cnr.ncsu.edu/index.php/BioRes/article/viewFile/BioRes_05_4_2221_Attiogbe_WMF_Peroxymonocarbonate_Anions_Bleach_Pt2_MechanicalPulps/711. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The reaction proceeds via a stereoselective nucleophilic substitution pathway.
Sitaram Bhavaraju 2016, 'Preparation of E-1,3-diaminoethenyl functional groups by the reaction of enol tosylateof alpha-formylglycine with primary and secondary amines', Current Chemistry Lettershttp://www.growingscience.com/ccl/Vol5/ccl_2016_1.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The esterification mechanism was proposed as a nucleophilic substitution reaction.
Huihui Wang, Wei Chen, Xueqin Zhang, Chuanfu Liu, Runcang Sun 2017, 'Esterification Mechanism of Bagasse Modified with Glutaric Anhydride in 1-Allyl-3-methylimidazoliumChloride', Materialshttps://www.mdpi.com/1996-1944/10/8/966. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Nucleophilic aromatic substitutions may play a role, and we speculate on possible chain polycondensation.
Anne Buyle Padias, Henry K. Hall, Jr. 2011, 'Mechanism Studies of LCP Synthesis', Polymershttp://www.mdpi.com/2073-4360/3/2/833/. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This transformation occurs via a nucleophilic substitution reaction.
Cíntia de A. Custódio, Simon J. Garden 2016, 'UM MÉTODO EFICIENTE PARA A OBTENÇÃO DE DERIVADOS DE 1-ALQUILAMINO-2,4-DINITROBENZENOE A REDUÇÃO REGIOSSELETIVA PARA A OBTENÇÃO DE DERIVADOS DE 1-ALQUILAMINO-2-AMINO-4-NITROBENZENO',Química Novahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422016000100049&lng=en&tlng=en. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The nucleophilic strength of ligand oxygen also determines the rate of exchange.
Erkki Aura 1980, 'Oxygen as an exchangeable ligand in soil', Agricultural and Food Sciencehttps://journal.fi/afs/article/view/72028. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Four directions for nucleophilic attack of water on phosphorus atom were defined.
Sofya V. Lushchekina, Lawrence M. Schopfer, Bella L. Grigorenko, Bella L. Grigorenko,Alexander V. Nemukhin, Alexander V. Nemukhin, Sergei D. Varfolomeev, Sergei D. Varfolomeev,Oksana Lockridge, Patrick Masson 2018, 'Optimization of Cholinesterase-Based Catalytic Bioscavengers Against OrganophosphorusAgents', Frontiers in Pharmacologyhttp://journal.frontiersin.org/article/10.3389/fphar.2018.00211/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, their high nucleophilic susceptibility means they are best prepared and used immediately.
Marcus Baumann, Ian R. Baxendale 2013, 'The rapid generation of isothiocyanates in flow', Beilstein Journal of Organic Chemistryhttps://doi.org/10.3762/bjoc.9.184. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Their reactivity towards electrophilic and nucleophilic reagents has been investigated.
Enchev Dobromir D. 2017, 'Synthesis and properties of N-alkyl(phenyl)amido-O-methyl-1,2-alkadienephosphonates',Acta Scientifica Naturalishttp://www.degruyter.com/view/j/asn.2017.4.issue-1/asn-2017-0002/asn-2017-0002.xml?format=INT. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The former sites are susceptible for electrophilic reactions while the latter for nucleophilic reactions.
Ethiraj Sathiyaraj, Marimuthu Venkatesh Perumal, Erumaippatty Rajagounder Nagarajan,Chennan Ramalingan 2018, 'Functionalized zinc(II) dithiocarbamate complexes: Synthesis, spectral and molecularstructures of bis(N-cyclopropyl-N-4-methoxybenzyldithiocarbamato-S,S′)zinc(II) and(2,2′-bipyridine)bis(N-cyclopropyl-N-4-methoxybenzyldithiocarbamato-S,S′)zinc(II)',Journal of Saudi Chemical Societyhttp://www.sciencedirect.com/science/article/pii/S1319610317301096. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)