Further, the formulation was found to be nonstinging, nonirritating, and noncomedogenic.
Heinicke IR, Adams DH, Barnes TM, Greive KA 2015, 'Evaluation of a topical treatment for the relief of sensitive skin', Clinical, Cosmetic and Investigational Dermatologyhttp://www.dovepress.com/evaluation-of-a-topical-treatment-for-the-relief-of-sensitive-skin-peer-reviewed-article-CCID. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Safety evaluation showed that the hydrolysate was nontoxic and nonirritating to skin.
Xiu-Lan Chen, Ming Peng, Jing Li, Bai-Lu Tang, Xuan Shao, Fang Zhao, Chang Liu, Xi-YingZhang, Ping-Yi Li, Mei Shi, Yu-Zhong Zhang, Xiao-Yan Song 2017, 'Preparation and functional evaluation of collagen oligopeptide-rich hydrolysate fromfish skin with the serine collagenolytic protease from Pseudoalteromonas sp. SM9913',Scientific Reportshttp://link.springer.com/article/10.1038/s41598-017-15971-9. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The formulations were found to be nonirritating with no ocular damage or abnormal clinical signs observed.
Fatima Sanjeri Dasankoppa, Seema Kujur, Hasan Pasha Nazeer Ahmed Sholapur, Vilas GJamakandi 2016, 'Design, formulation and evaluation of carboxy methyl tamarind based in situ gellingophthalmic drug delivery system of dorzolamide hydrochloride', Indian Journal of Health Sciences and Biomedical Research KLEUhttp://www.ijournalhs.org/article.asp?issn=2542-6214;year=2016;volume=9;issue=1;spage=56;epage=66;aulast=Dasankoppa. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)