a proteoglycan particularly known for its role in the development of the neuromuscular junction, when it is secreted by motor neuron axons
Examples of 'agrin' in a sentence
agrin
Sera were assayed for antibodies to agrin.
Bin Zhang, Chengyong Shen, Beverly Bealmear, Samia Ragheb, Wen-Cheng Xiong, RichardA. Lewis, Robert P. Lisak, Lin Mei 2014, 'Autoantibodies to Agrin in Myasthenia Gravis Patients', PLoS ONE10.1371/journal.pone.0091816. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Interestingly, cell lines originated from distinct sites showed different expressionof agrin and perlecan.
Rebeca Kawahara, Daniela C Granato, Carolina M Carnielli, Nilva K Cervigne, CarineE Oliveria, César Rivera, Sami Yokoo, Felipe P Fonseca, Marcio Lopes, Alan R Santos-Silva,Edgard Graner, Ricardo D Coletta, Adriana Franco Paes Leme 2014, 'Agrin and perlecan mediate tumorigenic processes in oral squamous cell carcinoma.',PLoS ONEhttp://europepmc.org/articles/PMC4266612?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Thus, the murine kidney expresses agrin and neurotrypsin in nephron segments beyond the glomerulum.
Arezoo Daryadel, Monika Haubitz, Marta Figueiredo, Dominik Steubl, Marcel Roos, ArminMäder, Stefan Hettwer, Carsten A. Wagner 2016, 'The C-Terminal Fragment of Agrin (CAF), a Novel Marker of Renal Function, Is Filteredby the Kidney and Reabsorbed by the Proximal Tubule', PLOS ONE10.1371/journal.pone.0157905. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This report demonstrates that a systemically administered agrin fragment has the potential to counteract the symptoms of neuromuscular disorders.
Stefan Hettwer, Shuo Lin, Stefan Kucsera, Monika Haubitz, Filippo Oliveri, RuggeroG. Fariello, Markus A. Ruegg, Jan W. Vrijbloed 2014, 'Injection of a Soluble Fragment of Neural Agrin (NT-1654) Considerably Improves theMuscle Pathology Caused by the Disassembly of the Neuromuscular Junction', PLoS ONE10.1371/journal.pone.0088739. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
None of the 25 healthy controls and none of the 55 control neurological patients had agrin antibodies.
Bin Zhang, Chengyong Shen, Beverly Bealmear, Samia Ragheb, Wen-Cheng Xiong, RichardA. Lewis, Robert P. Lisak, Lin Mei 2014, 'Autoantibodies to Agrin in Myasthenia Gravis Patients', PLoS ONE10.1371/journal.pone.0091816. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)