of or pertaining to the control of the nutrition and metabolism of cells by the nervous system
neurotrophic in American English
(ˌnurəˈtrɑfɪk, -ˈtroufɪk, ˌnjur-)
adjective
1.
of or pertaining to the effect of nerves on the nutritive processes
2.
neurotropic
Word origin
[1895–1900; neuro- + -trophic]
Examples of 'neurotrophic' in a sentence
neurotrophic
This transcriptional signature may be mediated by reduced brain-derived neurotrophic factor expression.
Elena G. Bochukova, Katherine Lawler, Sophie Croizier, Julia M. Keogh, Nisha Patel,Garth Strohbehn, Kitty K. Lo, Jack Humphrey, Anita Hokken-Koelega, Layla Damen, StephanyDonze, Sebastien G. Bouret, Vincent Plagnol, I. Sadaf Farooqi 2018, 'A Transcriptomic Signature of the Hypothalamic Response to Fasting and BDNF Deficiencyin Prader-Willi Syndrome', Cell Reportshttp://www.sciencedirect.com/science/article/pii/S2211124718303474. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Small natural molecules, such as resveratrol, may influence neurotrophic factors ofthe retina.
Popescu M, Bogdan C, Pintea A, Rugină D, Ionescu C 2018, 'Antiangiogenic cytokines as potential new therapeutic targets for resveratrol in diabeticretinopathy', Drug Design, Development and Therapyhttps://www.dovepress.com/antiangiogenic-cytokines-as-potential-new-therapeutic-targets-for-resv-peer-reviewed-article-DDDT. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Neurotrophic factors play key roles in the development and survival of neurons.
Atsuko Kimura, Kazuhiko Namekata, Xiaoli Guo, Chikako Harada, Takayuki Harada 2016, 'Neuroprotection, Growth Factors and BDNF-TrkB Signalling in Retinal Degeneration',International Journal of Molecular Scienceshttp://www.mdpi.com/1422-0067/17/9/1584. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Exercise also improves neural function by increasing neurotrophic factors.
Jin-Young Chung, Min-Wook Kim, Moon-Suk Bang, Manho Kim 2013, 'Increased Expression of Neurotrophin 4 Following Focal Cerebral Ischemia in AdultRat Brain with Treadmill Exercise', PLoS ONE10.1371/journal.pone.0052461. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
She developed neurotrophic ulcer in the right eye with lagophthalmos post-surgery.
Areekkat Manojkumar, A R Aramya 2013, 'Post-surgical management of pontine hemorrhage with Ayurvedic treatment', Ancient Science of Lifehttp://www.ancientscienceoflife.org/article.asp?issn=0257-7941;year=2013;volume=32;issue=4;spage=250;epage=252;aulast=Manojkumar. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
How neurotrophic factors regulate these latter proteins remains, however, poorly defined.
Elisabetta Menna, Andrea Disanza, Cinzia Cagnoli, Ursula Schenk, Giuliana Gelsomino,Emanuela Frittoli, Maud Hertzog, Nina Offenhauser, Corinna Sawallisch, Hans-JürgenKreienkamp, Frank B Gertler, Pier Paolo Di Fiore, Giorgio Scita, Michela Matteoli 2009, 'Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derivedneurotrophic factor (BDNF).', PLoS Biologyhttp://europepmc.org/articles/PMC2696597?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
They also can secrete neurotrophic factors to promote axonal growth, and remyelination.
Liangfu Jiang, Salazar Jones, Xiaofeng Jia 2017, 'Stem Cell Transplantation for Peripheral Nerve Regeneration: Current Options and Opportunities',International Journal of Molecular Scienceshttp://www.mdpi.com/1422-0067/18/1/94. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Therefore, interfering with neurotrophic signaling seems an attractive strategy to achieve neuroprotection.
Eline Dekeyster, Emiel Geeraerts, Tom Buyens, Chris Van den Haute, Veerle Baekelandt,Lies De Groef, Manuel Salinas-Navarro, Lieve Moons 2015, 'Tackling Glaucoma from within the Brain: An Unfortunate Interplay of BDNF and TrkB.',PLoS ONEhttp://europepmc.org/articles/PMC4641732?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Interestingly, this response was accompanied by neurotrophic factor upregulation.
Yagya V Sharma, Radu I Cojocaru, Linda M Ritter, Nidhi Khattree, Matthew Brooks, AlisonScott, Anand Swaroop, Andrew F X Goldberg 2012, 'Protective gene expression changes elicited by an inherited defect in photoreceptorstructure.', PLoS ONEhttp://europepmc.org/articles/PMC3282697?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The impact of this denervation can range from mild discomfort to neurotrophic corneas.
Francisco Bandeira, Nur Zahira Yusoff, Gary Hin-Fai Yam, Jodhbir Singh Mehta 2019, 'Corneal re-innervation following refractive surgery treatments', Neural Regeneration Researchhttp://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=4;spage=557;epage=565;aulast=Bandeira. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)