any of the embryonic cells from which the nerve cells develop
Word origin
neuro- + -blast
neuroblast in American English
(ˈnurəˌblæst, ˈnjur-)
noun
an immature nerve cell
Derived forms
neuroblastic
adjective
Word origin
[1890–95; neuro- + -blast]
Examples of 'neuroblast' in a sentence
neuroblast
Calpastatin deletion impaired both neural stem cell proliferation and neuroblast migration.
Vanessa Mendes Machado, Vanessa Mendes Machado, Vanessa Mendes Machado, Maria InêsMorte, Bruno Pereira Carreira, Maria Manuela Azevedo, Maria Manuela Azevedo, JiroeTakano, Nobuhisa eIwata, Takaomi C Saido, Hannelore eAsmussen, Alan Rick Horwitz,Caetana Monteiro Carvalho, Inês Maria Araújo, Inês Maria Araújo, Inês Maria Araújo 2015, 'Involvement of calpains in adult neurogenesis: implications for stroke', Frontiers in Cellular Neurosciencehttp://journal.frontiersin.org/Journal/10.3389/fncel.2015.00022/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, prolonged hypothyroidism reduced not only neuroblast numbers but also their mitochondrial activity.
J.D. Gothié, A. Sébillot, C. Luongo, M. Legendre, C. Nguyen Van, K. Le Blay, M. Perret-Jeanneret,S. Remaud, B.A. Demeneix 2017, 'Adult neural stem cell fate is determined by thyroid hormone activation of mitochondrialmetabolism', Molecular Metabolismhttp://www.sciencedirect.com/science/article/pii/S2212877817305689. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Moreover, artificial laminin-containing scaffolds promoted neuroblast chain formation and migration toward the injured area.
Teppei Fujioka, Naoko Kaneko, Itsuki Ajioka, Kanako Nakaguchi, Taichi Omata, HonokaOhba, Reinhard Fässler, José Manuel García-Verdugo, Kiyotoshi Sekiguchi, NoriyukiMatsukawa, Kazunobu Sawamoto 2017, 'β1 integrin signaling promotes neuronal migration along vascular scaffolds in thepost-stroke brain', EBioMedicinehttp://www.sciencedirect.com/science/article/pii/S2352396417300051. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Neuroblast chains migrate through the rostral migratory stream ensheathed by astrocytic processes.
Archana eGengatharan, Rodrigo Roberto Bammann, Armen eSaghatelyan 2016, 'The role of astrocytes in the generation, migration and integration of new neuronsin the adult olfactory bulb', Frontiers in Neurosciencehttp://journal.frontiersin.org/Journal/10.3389/fnins.2016.00149/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The best models consistently show self-renewal of transit-amplifying progenitors and rapid neuroblast cell cycle exit.
Lisa Bast, Filippo Calzolari, Michael K. Strasser, Jan Hasenauer, Fabian J. Theis,Jovica Ninkovic, Carsten Marr 2018, 'Increasing Neural Stem Cell Division Asymmetry and Quiescence Are Predicted to Contributeto the Age-Related Decline in Neurogenesis', Cell Reportshttp://www.sciencedirect.com/science/article/pii/S2211124718318795. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These progenitors express neither canonical neuroblast nor lamina precursor cell markers.
Zhenqing Chen, Alberto Del Valle Rodriguez, Xin Li, Ted Erclik, Vilaiwan M. Fernandes,Claude Desplan 2016, 'A Unique Class of Neural Progenitors in the Drosophila Optic Lobe Generates Both MigratingNeurons and Glia', Cell Reportshttp://www.sciencedirect.com/science/article/pii/S2211124716303321. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This phenomenon resulted from an inhibition of neuroblast proliferation and a concomitant increase in apoptosis.
Xavier Valentini, Pauline Deneufbourg, Paula Paci, Pascaline Rugira, Sophie Laurent,Annica Frau, Dimitri Stanicki, Laurence Ris, Denis Nonclercq 2018, 'Morphological alterations induced by the exposure to TiO2 nanoparticles in primarycortical neuron cultures and in the brain of rats', Toxicology Reportshttp://www.sciencedirect.com/science/article/pii/S2214750018304803. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Moreover, hemopexin deletion resulted in impaired neuroblast migration in the rostralmigratory stream.
Yanling Zhu, Yang Qiu, Mengjia Chen, Yi Zhang, Li Cao, Zhida Su, Yimin Yuan, AijunHuang, Yinyan Pu, Cheng He 2018, 'Hemopexin is required for adult neurogenesis in the subventricular zone/olfactorybulb pathway', Cell Death and Diseasehttp://link.springer.com/article/10.1038/s41419-018-0328-0. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Fgf initiates neuroblast specification within the ear.
Husniye Kantarci, Renee K Edlund, Andrew K Groves, Bruce B Riley 2015, 'Tfap2a promotes specification and maturation of neurons in the inner ear through modulationof Bmp, Fgf and notch signaling.', PLoS Geneticshttp://europepmc.org/articles/PMC4364372?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
It functions in brain embryonic development and in response to ischemic injury in helping guide neuroblast migration and vasculogenesis.
Walker Aisha L, Wimborne Hereward JC, Bartley John H, Miller Jason T, Hess David C,Hill William D, Carroll James E 2005, 'The neuroblast and angioblast chemotaxic factor SDF-1 (CXCL12) expression is brieflyup regulated by reactive astrocytes in brain following neonatal hypoxic-ischemic injury',BMC Neurosciencehttp://www.biomedcentral.com/1471-2202/6/63. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)