However, mechanisms of diabetogenic action appeared divergent based on dose.
Marina Cetkovic-Cvrlje, Sinduja Thinamany, Kylie A. Bruner 2017, 'Bisphenol A (BPA) aggravates multiple low-dose streptozotocin-induced Type 1 diabetesin C57BL/6 mice', Journal of Immunotoxicologyhttp://dx.doi.org/10.1080/1547691X.2017.1334722. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Therefore, the diabetogenic effect of hyperthyroxinemia should not be overlooked.
M. Suttan Assin, Jusuf Rukman, Jose R. L. Batubara, Purnama Wati S. P. 2019, 'Graves' Disease and Diabetes Mellitus', Paediatrica Indonesianahttps://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/2125. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This observation necessitated the review of alloxan as a diabetogenic agent in animal studies.
Osasenaga Macdonald Ighodaro, Abiola Mohammed Adeosun, Oluseyi Adeboye Akinloye 2017, 'Alloxan-induced diabetes, a common model for evaluating the glycemic-control potentialof therapeutic compounds and plants extracts in experimental studies', Medicinahttp://www.sciencedirect.com/science/article/pii/S1010660X18300107. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The electrostatic potential within the peptide binding pocket exerts a strong influence on diabetogenic epitopes with basic residues.
Brooks Bernard R, Parry Christian S 2008, 'A new model defines the minimal set of polymorphism in HLA-DQ and -DR that determinessusceptibility and resistance to autoimmune diabetes', Biology Directhttp://www.biology-direct.com/content/3/1/42. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These results reinforce the contribution of an abdominal obesity phenotype associated with a diabetogenic and atherothrombotic profile to liver lipotoxicity.
Paulo M. Rocha, José T. Barata, Cláudia S. Minderico, Analiza M. Silva, Pedro J. Teixeira,Luís B. Sardinha 2011, 'Visceral Abdominal and Subfascial Femoral Adipose Tissue Have Opposite Associationswith Liver Fat in Overweight and Obese Premenopausal Caucasian Women', Journal of Lipidshttp://dx.doi.org/10.1155/2011/154672. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The effect of dermcidin as a diabetogenic and a hypertensive agent could be controlledeither by aspirin or by insulin.
Rajeshwary Ghosh, Sarbashri Bank, Rabindra Bhattacharya, Nighat N. Khan, A. KumarSinha 2014, 'Neutralization by Insulin of the Hypertensive Effect of Dermcidin Isoform 2: An EnvironmentallyInduced Diabetogenic and Hypertensive Protein', Cardiology Research and Practicehttp://dx.doi.org/10.1155/2014/412815. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
A major meta-analysis has confirmed the ability of statins to exert both diabetogenic and hyperglycaemic effects.
Olga A. Koshelskaya, Anastasiya S. Sushkova, Olga A. Zhuravleva, Irina V. Vinnizkaya,Nataliya G. Brazovskaya, Elena S. Kravchenko, Tatyana E. Suslova, Rostislav S. Karpov 2017, 'Prediction of basal glycaemia dynamics during treatment with 6-month lipid-loweringtherapy in patients at high risk of cardiovascular disease', Saharnyj Diabethttps://endojournals.ru/index.php/dia/article/view/8633. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
It has been recognized that apart from their beneficial lipid lowering effects, statins also exhibit diabetogenic properties.
Vishal A. Salunkhe, Olof Elvstam, Lena Eliasson, Anna Wendt 2016, 'Rosuvastatin Treatment Affects Both Basal and Glucose-Induced Insulin Secretion inINS-1 832/13 Cells', PLOS ONE10.1371/journal.pone.0151592. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Alloxan and streptozotocin are the most popular diabetogenic agents used for assessing the antidiabetic or hypoglycemic capacity of test compounds.
Osasenaga Macdonald Ighodaro, Abiola Mohammed Adeosun, Oluseyi Adeboye Akinloye 2017, 'Alloxan-induced diabetes, a common model for evaluating the glycemic-control potentialof therapeutic compounds and plants extracts in experimental studies', Medicinahttp://www.sciencedirect.com/science/article/pii/S1010660X18300107. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This circumstance dictates the need for anti dysbiotic prophylaxis and therapy of diabetogenic complications in the oral cavity tissues.
E. P. Stupak 2016, 'Дисбиотические процессы в тканях полости рта крыс при экспериментальном сахарном диабете= Dysbiotic processes in rats oral cavity tissues in experimental diabetes mellitus',Journal of Education, Health and Sporthttp://www.ojs.ukw.edu.pl/index.php/johs/article/view/3924. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)