Keratin filaments were not attached to the desmosomal plaque.
Hiram Larangeira de Almeida Jr, Miriam Nakagami Sotto, Luis Antonio Suita de Castro,Nara Moreira Rocha 2008, 'Transmission electron microscopy of the preclinical phase of experimental phytophotodermatitis',Clinicshttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322008000300014. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The genetic cause remains unknown in ~50% of probands with routine desmosomal gene screening.
Joel Fedida, Veronique Fressart, Philippe Charron, Elodie Surget, Tiphaine Hery, PascaleRichard, Erwan Donal, Boris Keren, Guillaume Duthoit, Françoise Hidden-Lucet, EricVillard, Estelle Gandjbakhch 2017, 'Contribution of exome sequencing for genetic diagnostic in arrhythmogenic right ventricularcardiomyopathy/dysplasia.', PLoS ONEhttp://europepmc.org/articles/PMC5540585?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These junctions are connected directly with desmosomal cadherin proteins.
Yasuo Kitajima 2013, 'New insights into desmosome regulation and pemphigus blistering as a desmosome-remodelingdisease', Kaohsiung Journal of Medical Scienceshttp://www.sciencedirect.com/science/article/pii/S1607551X12002021. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The structure, function, and regulation of desmosomal adhesion in vivo are discussed.
David Garrod 2010, 'Desmosomes In Vivo', Dermatology Research and Practicehttp://dx.doi.org/10.1155/2010/212439. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Immunohisto - chemical analysis did not suggest desmosomal pathology.
Laura Ollila, Johanna Kuusisto, Keijo Peuhkurinen, Satu Kärkkäinen, Petri Tuomainen,Maija Kaartinen, Olayinka Raheem, Bjarne Udd, Jarkko Magga, Janne Rapola, AnnukkaM. Lahtinen, Eero Lehtonen, Miia Holmström, Sari Kivistö, Elisabeth Widén, MarkkuSaksa, Tiina Heliö 2013, 'Lamin A/C mutation affecting primarily the right side of the heart', Cardiogeneticshttp://www.pagepressjournals.org/index.php/cardiogen/article/view/673. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Together, these studies suggest a role for desmosomal adhesion in efficient wound healing.
Veronica G. Beaudry, Rebecca A. Ihrie, Suzanne B. R. Jacobs, Bichchau Nguyen, NavneetaPathak, Eunice Park, Laura D. Attardi 2010, 'Loss of the Desmosomal Component Perp Impairs Wound Healing In Vivo', Dermatology Research and Practicehttp://dx.doi.org/10.1155/2010/759731. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
No changes in desmosomal proteins or ultrastructure other than increased plakophilin-3were observed.
Emily Diane Wickline, Yu Du, Donna B. Stolz, Michael Kahn, Satdarshan P.S. Monga 2013, 'γ-Catenin at Adherens Junctions: Mechanism and Biologic Implications in HepatocellularCancer after β-Catenin Knockdown', Neoplasia: An International Journal for Oncology Researchhttp://www.sciencedirect.com/science/article/pii/S1476558613800498. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
After one hour, desmosomal changes were also observed in addition to vacuolization.
Hiram Larangeira de Almeida Jr, Miriam Nakagami Sotto, Luis Antonio Suita de Castro,Nara Moreira Rocha 2008, 'Transmission electron microscopy of the preclinical phase of experimental phytophotodermatitis',Clinicshttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322008000300014. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)