Flank marking was significantly inhibited in animals treated with fluoxetine or clomipramine but unaffected by treatment with desipramine.
Messenger Tara, Rasmussen Mads F, Ferris Craig F, Koppel Gary 2001, 'Vasopressin-dependent flank marking in golden hamsters is suppressed by drugs usedin the treatment of obsessive-compulsive disorder', BMC Neurosciencehttp://www.biomedcentral.com/1471-2202/2/10. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Predictions were that amitriptyline would decrease maternal behavior and increase aggression relative to desipramine, particularly at higher doses.
Elizabeth Thomas Cox, Thomas Merryfield Jarrett, Thomas Merryfield Jarrett, MatthewStephen McMurray, Kevin eGreenhill, Vivian E Hofler, Sarah Kaye Williams, Paul WaylandJoyner, Christopher L Middleton, Cheryl H Walker, Josephine M Johns, Josephine M Johns,Josephine M Johns 2011, 'Combined Norepinephrine / Serotonergic Reuptake Inhibition: Effects on Maternal Behavior,Aggression and Oxytocin in the Rat', Frontiers in Psychiatryhttp://journal.frontiersin.org/Journal/10.3389/fpsyt.2011.00034/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Good therapeutic response to noradrenergic agents, like desipramine and reboxetine, though not frequentlyreported in literature, has already been demonstrated.
Simone Mancini Castilho, Luiz Henrique Viegas Costa 2003, 'Reboxetina no tratamento da bulimia nervosa Reboxetine in the treatment of bulimianervosa', Revista Brasileira de Psiquiatriahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462003000200010. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Amitriptyline, mirtazapine, desipramine, venlafaxine, fluoxetine, and nortriptylineshowed the highest placebo effect-adjusted risk of adverse effects.
Carina Riediger, Carina Riediger, Tibor Schuster, Kristian Barlinn, Sarah Maier, SarahMaier, Sarah Maier, Jürgen Weitz, Timo Siepmann, Timo Siepmann 2017, 'Adverse Effects of Antidepressants for Chronic Pain: A Systematic Review and Meta-analysis',Frontiers in Neurologyhttp://journal.frontiersin.org/article/10.3389/fneur.2017.00307/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)