a cellular process in which cytoplasmic granules within certain cells secrete their contents, often to the outside of the cell
degranulation in American English
(diˌɡrænjəˈleiʃən)
noun
the loss or elimination of granules
Word origin
[1940–45; de- + granulation]This word is first recorded in the period 1940–45. Other words that entered Englishat around the same time include: airlift, blockbuster, set-aside, update, zapde- is a prefix occurring in loanwords from Latin (decide); also used to indicate privation, removal, and separation (dehumidify), negation (demerit; derange), descent (degrade; deduce), reversal (detract), or intensity (decompound)
Examples of 'degranulation' in a sentence
degranulation
However, the mechanisms that control neutrophil degranulation are not well understood.
Lacy Paige 2006, 'Mechanisms of Degranulation in Neutrophils', Allergy, Asthma & Clinical Immunologyhttp://www.aacijournal.com/content/2/3/98. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Degranulation was measured by the release of β-hexosaminidase.
Adriana Catalli, Victor Karpov, Levente E. Erdos, Brian P. Tancowny, Robert P. Schleimer,Marianna Kulka 2014, 'Stimulus-Selective Regulation of Human Mast Cell Gene Expression, Degranulation andLeukotriene Production by Fluticasone and Salmeterol', PLoS ONE10.1371/journal.pone.0096891. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
On the other hand, the degranulation activity remained reduced.
Carsten Gründemann, Kathrin Thell, Karin Lengen, Manuel Garcia-Käufer, Yen-Hua Huang,Roman Huber, David J Craik, Gernot Schabbauer, Christian W Gruber 2013, 'Cyclotides Suppress Human T-Lymphocyte Proliferation by an Interleukin 2-DependentMechanism.', PLoS ONEhttp://europepmc.org/articles/PMC3694003?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Nociceptive stimuli cause mast cell degranulation and the release of substances contained in the granules.
Guido Orlandini 2011, 'Glia, mast cells and related: new therapeutic perspectives?', Pathoshttp://www.pathos-journal.com/page_44.html. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Neutrophils participate in the maintenance of host integrity by releasing various cytotoxic proteins during degranulation.
Isabelle Naegelen, Nicolas Beaume, Sébastien Plançon, Véronique Schenten, Eric J.Tschirhart, Sabrina Bréchard 2015, 'Regulation of Neutrophil Degranulation and Cytokine Secretion: A Novel Model ApproachBased on Linear Fitting', Journal of Immunology Researchhttp://dx.doi.org/10.1155/2015/817038. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The symptoms and complications are mostly in proportion to the mast cell degranulation in tissues.
Dinesh Prasad Asati, Anurag Tiwari 2014, 'Bullous mastocytosis in a 3-month-old infant', Indian Dermatology Online Journalhttp://www.idoj.in/article.asp?issn=2229-5178;year=2014;volume=5;issue=4;spage=497;epage=500;aulast=Asati. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Our previous studies have demonstrated that mast cell degranulation can directly induce microglia activation.
Hongquan Dong, Hongquan Dong, Yiming Wang, Yiming Wang, Xiaojun Zhang, Xiang Zhang,Yanning Qian, Haixia Ding, Shu Zhang 2019, 'Stabilization of Brain Mast Cells Alleviates LPS-Induced Neuroinflammation by InhibitingMicroglia Activation', Frontiers in Cellular Neurosciencehttps://www.frontiersin.org/article/10.3389/fncel.2019.00191/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Further provocation with antigen leads to degranulation of eosinophils and ulceration of the bronchial mucosa.
José R Lapa e Silva, C Ruffié, J Lefort, M Pretolani, BB Vargaftig 1997, 'Role of eosinophilic airway inflammation in models of asthma', Memórias do Instituto Oswaldo Cruz.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761997000800032. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The basophils also go into degeneration and degranulation at 72 hours.
Okhandiar R, Sharma H 1993, 'Basophil leucocyte response in leprosy with lepromin-A', Indian Journal of Dermatology, Venereology and Leprologyhttp://www.ijdvl.com/article.asp?issn=0378-6323;year=1993;volume=59;issue=4;spage=176;epage=183;aulast=Okhandiar. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)